78564-14-4

Upstream product

• 22966-25-2 (E)-1-(4-fluorophenyl)-3-phenyl-2-propen-1-one 
• 109-77-3 malononitrile 
• 399-10-0 4'-fluorochalcone 

Downstream Products

• 94360-53-9 (2R,3S)-2-(4-Fluoro-benzoyl)-3-phenyl-cyclopropane-1,1-dicarbonitrile 
• 94360-68-6 2-[3-Cyano-6-(4-fluoro-phenyl)-4-phenyl-pyridin-2-ylsulfanyl]-acetamide 
• 94360-73-3 [3-Cyano-6-(4-fluoro-phenyl)-4-phenyl-pyridin-2-ylsulfanyl]-acetic acid methyl ester 
• 94360-78-8 ethyl 2-(3-cyano-6-(4-fluorophenyl)-4-phenylpyridin-2-ylthio)acetate 
• 94360-41-5 6'-(4-Fluoro-phenyl)-4'-phenyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile 
• 94360-48-2 2-Azepan-1-yl-6-(4-fluoro-phenyl)-4-phenyl-nicotinonitrile 
• 94360-47-1 6-(4-Fluoro-phenyl)-2-morpholin-4-yl-4-phenyl-nicotinonitrile 
• 94360-87-9 6-(4-Fluoro-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-4-phenyl-nicotinonitrile 
• 78564-39-3 8-amino-4-phenyl-2-(4-fluorophenyl)pyrido<2',3':2,3>thieno<4,5-d>pyrimidine 
• 78564-35-9 3-Amino-6-(4-fluoro-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile 
• 94360-10-8 2-Bromo-2-[3-(4-fluoro-phenyl)-3-oxo-1-phenyl-propyl]-malononitrile 
• 94360-24-4 2-Bromo-6-(4-fluoro-phenyl)-4-phenyl-nicotinonitrile 
• 78564-20-2 6-(4-Fluoro-phenyl)-4-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 1040232-80-1 (S)-2-[3-(4-fluorophenyl)-3-oxo-1-phenylpropyl]malononitrile 

Relevant academic research and scientific papers

Cu(II)-Promoted Cascade Synthesis of Fused Imidazo-Pyridine-Carbonitriles

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition-cyclization reaction followed by an Ullmann-type C-N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32-84% yields. The compounds show excellent photoluminescence properties having two absorption maxima in the region between 270-280 and 338-350 nm and emission maxima in the range of 502-533 nm. The HOMO-LUMO energy gap of 3.49-3.57 eV was determined using Gaussian 09 at the B3LYP/6-31G (d, p) basis set level. We also demonstrated a few postsynthetic modifications.

Visible-light-accelerated pd-catalyzed cascade addition/ cyclization of arylboronic acids to γ- And β-ketodinitriles for the construction of 3-cyanopyridines and 3-cyanopyrrole analogues

The one-pot synthetic strategies for 2,4,6-triarylnicotinonitriles and 2,5-diaryl-1H-pyrrole-3-carbonitriles have been accomplished via a Pd-catalyzed coupling of arylboronic acid with 2-(3-oxo-1,3-diarylpropyl)malononitrile and 2-(2-oxo-2- arylethyl)malo

Immobilization of lipase on Fe3O4/ZnO core/shell magnetic nanoparticles and catalysis of Michael-type addition to chalcone derivatives

Fe3O4/ZnO core/shell magnetic nanoparticles in 1:1 and 1:2 molar ratios were prepared and characterized by using X-ray powder diffraction, scanning electron microscopy, thermogravimetric analysis, FT-IR spectra, and flame atomic abso

SYNTHESIS AND SOME REACTIONS OF 3-CYANOPYRIDINE-2-THIONES

New method for the synthesis of 3-cyanopyridine-2-thiones by the reaction of δ-keto nitroles with sulfur and by condensation of chalcones or benzylideneacetone with cyanothioacetamide are given.The compounds obtained were used in various reactions for the preparation of alkylated products, disulfides, and condensed heterocycles, viz., thienopyridines and pyridothienopyrimidines.