785777-99-3Relevant articles and documents
Brominated 4-(trifluoromethyl)pyrimidines: A convenient access to versatile intermediates
Ondi, Levente,Lefebvre, Olivier,Schlosser, Manfred
, p. 3714 - 3718 (2004)
An expedient route to all three monobrominated and all three dibrominated isomers of 4-(trifluoromethyl)pyrimidine, and to several other halogenated pyrimidines, is described. Key steps are the electrophilic introduction of the halogen in the 5-position of 2- or 4-pyrimidinones, the bromodeoxygenation of pyrimidinones or thiopyrimidinones using phosphorus tribromide, and the partial debromination of dibromo-4-(trifluoromethyl)pyrimidines. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.