78588-03-1

Basic information

• Product Name: 3-(4-chlorophenyl)quinolin-2(1H)-one
• Synonyms: 3-(4-chlorophenyl)quinolin-2(1H)-one
• CAS NO: 78588-03-1
• Molecular Weight: 255.703
• Mol File: 78588-03-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)quinolin-2(1H)-one(78588-03-1)
• EPA Substance Registry System: 3-(4-chlorophenyl)quinolin-2(1H)-one(78588-03-1)

Safety Data

• Hazardous Substances Data: 78588-03-1(Hazardous Substances Data)

Upstream product

• 59-31-4 2-quinolone 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 33768-43-3 N-(2-formylphenyl)benzamide 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 552-89-6 2-nitro-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 15184-98-2 N,N-dimethyl-4-chlorobenzylamine 
• 13939-06-5 molybdenum hexacarbonyl 
• 271-58-9 anthranil 
• 873-73-4 4-n-chlorophenylacetylene 
• 615-43-0 2-iodophenylamine 
• 144-62-7 oxalic acid 
• 10113-39-0 N-formyl-2-iodoaniline 
• 1176043-30-3 C₁₅H₈ClN 

Relevant articles and documents

Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1: H)-ones

An efficient carbonylative procedure for the synthesis of 3-arylquinoin-2(1H)-ones has been established. Through a palladium-catalyzed aminocarbonylation of benzyl chlorides with anthranils, a variety of 3-arylquinoin-2(1H)-one products were obtained in moderate to excellent yields with good functional group tolerance. This journal is

Palladium-catalyzed carbonylative synthesis of 3-arylquinolin-2(1H)-ones from benzyl chlorides and o-nitrobenzaldehydes

A palladium-catalyzed carbonylative cyclization of benzyl chlorides with o-nitrobenzaldehydes has been developed for the synthesis of 3-arylquinolin-2(1H)-ones. Mo(CO)6 played a dual role as both a CO surrogate and a reductant in this carbonylative transformation.

Supported Palladium Nanoparticles-Catalyzed Synthesis of 3-Substituted 2-Quinolones from 2-Iodoanilines and Alkynes Using Oxalic Acid as C1 Source

3-Aryl/alkyl-2-quinolones were synthesized employing microwave assisted multicomponent reaction of 2-iodoanilines, terminal alkynes and oxalic acid dihydrate ((CO2H)2 ? 2H2O) under polystyrene supported palladium (Pd@PS) nanoparticles-catalyzed conditions. The use of a heterogeneous palladium catalyst was explored first time for 2-quinolone synthesis involving carbonylation reaction employing (CO2H)2 ? 2H2O as a solid and bench stable carbon monoxide (CO) source. The reaction exhibited good substrate generality for 2-iodoanilines and alkynes with wide functional group tolerance and good regio-selectivity. The ligand free operation, recyclability of heterogeneous Pd@PS catalyst and use of bench stable C1 source are the invaluable merits of the protocol. (Figure presented.).