78605-10-4

Basic information

• Product Name: 2-PHENYL-4,7-DIAZAINDOLE
• Synonyms: 2-PHENYL-4,7-DIAZAINDOLE;6-PHENYL-5H-PYRROLO[2,3-B]PYRAZINE;5H-Pyrrolo[2,3-b]pyrazine,6-phenyl-
• CAS NO: 78605-10-4
• Molecular Formula: C₁₂H₉N₃
• Molecular Weight: 195.22
• Product Categories: Azaindoles
• Mol File: 78605-10-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 216 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.27g/cm³
• Refractive Index: 1.699
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.73±0.20(Predicted)
• CAS DataBase Reference: 2-PHENYL-4,7-DIAZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-4,7-DIAZAINDOLE(78605-10-4)
• EPA Substance Registry System: 2-PHENYL-4,7-DIAZAINDOLE(78605-10-4)

Safety Data

• Hazardous Substances Data: 78605-10-4(Hazardous Substances Data)

Usage

General Description

2-Phenyl-4, 7-Diazaindole is a chemical compound under the category of indoles and derivatives. It has a molar mass of 197.22 g/mol and appears as a off-white to faint yellowish solid. 2-PHENYL-4,7-DIAZAINDOLE's molecular formula is C13H10N2. Often used in research and scientific studies, its primary applications include serving as a starting material for the synthesis of various complex molecules or for developing pharmaceutical and agrochemical products. Due to its inherent properties and structure, 2-Phenyl-4,7-Diazaindole exhibits potential activity as a biomaterial and can also be used as a dopant for enhancing material properties. However, handling requires caution as its health effects are not completely known.

InChI:InChI=1/C12H9N3/c1-2-4-9(5-3-1)10-8-11-12(15-10)14-7-6-13-11/h1-8H,(H,14,15)

Upstream product

• 109-08-0 2-Methylpyrazine 
• 100-47-0 benzonitrile 
• 908833-92-1 3-di-(tert-butoxycarbonyl)amino-pyrazine-2-carboxylic acid methyl ester 
• 5424-01-1 3-aminopyrazinoic acid 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 536-74-3 phenylacetylene 
• 1349151-88-7 5-bromo-3-(phenylethynyl)pyrazin-2-amine 
• 798544-32-8 3-phenylethynyl-pyrazin-2-ylamine 
• 724442-38-0 N-(3-chloropyrazin-2-yl)-methanesulfonamide 

Downstream Products

• 1255761-94-4 1,3,7-triphenyl-3H-pyrrolo[2,3-e]-1,2,4-triazolo[4,3-a]pyrazine 
• 1255761-92-2 1,3,7-triphenyl-5,6-dihydro-3H-pyrrolo[2,3-e]-1,2,4-triazolo[4,3-a]pyrazine 
• 1255761-96-6 1,3,7-triphenyl-6-[1-phenyl-N-phenyl-2-ethanehydrazonyl]-5,6-dihydro-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine 
• 1255761-91-1 1-acetyl-3,7-diphenyl-5,6-dihydro-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine 
• 1255761-89-7 3,9-diacetyl-1,6,11-triphenyl-[1,11,11a,11b-tetrahydrobis-1,2,4-triazolo[3,4-c:4',3'-a]-3H-pyrrolo[2,3-e]pyrazine] 
• 1255761-93-3 ethyl 3-(4-chlorophenyl)-7-phenyl-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine-1-carboxylate 
• 1255761-90-0 ethyl 3-(p-chlorophenyl)-7-phenyl-5,6-dihydro-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine-1-carboxylate 
• 1255761-88-6 1,11-bis-(4-chlorophenyl)-3,9-diethoxycarbonyl-6-phenyl-[1,11,11a,11b-tetrahydrobis[1,2,4]triazolo[3,4-c:4',3'-a]-3H-pyrrolo[2,3-e]pyrazine] 
• 1255761-95-5 3-(4-chlorophenyl)-6-[ethoxy-N-(4-chlorophenyl)-2-oxoethanehydrazonyl]-7-phenyl-5,6-dihydro-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine-1-carboxylate 
• 1255761-86-4 methyl 3,7-diphenyl-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine-1-carboxylate 
• 1255761-85-3 methyl 3,7-diphenyl-5,6-dihydro-3H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazine-1-carboxylate 
• 1255761-84-2 3,9-dimethoxycarbonyl-1,6,11-triphenyl-[1,11,11a,11b-tetrahydrobis-1,2,4-triazolo[3,4-c:4',3'-a]-1H-pyrrolo[2,3-e]pyrazine] 
• 1255761-87-5 6-[methoxy-N-phenyl-2-oxoethanehydrazonyl]-3,7-diphenyl-5,6-dihydro-3H-pyrrolo-[2,3-e][1,2,4]triazolo[4,3-a]pyrazine-1-carboxylate 

Relevant articles and documents

Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes

A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.

AMIDE DERIVATIVES AND DRUGS

The present invention provides an amide derivative represented by the following formula [1]: wherein n represents 0 or 1; X represents CR4 or N; Y represents CR6 or N; Z represents CR7 or N; R1 and R2 may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R4, R5, R6 and R7 may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R3 represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. The compound of the present invention is useful as a TGF-β inhibitor.

6-Substituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation from N-(3-chloropyrazin-2-yl)-methanesulfonamide and alkynes

We herein report the efficient and convenient synthesis of 6-substituted-5H-pyrrolo[2,3-b]pyrazines. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired pyrrolo[2,3-b]pyrazine substrates. The reacti