78628-81-6

Basic information

• Product Name: (Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine
• Synonyms: (Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine
• CAS NO: 78628-81-6
• Molecular Formula: C₂₁H₂₅N
• Molecular Weight: 291.4299
• Mol File: 78628-81-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 417.9±33.0 °C(Predicted)
• Appearance: /
• Density: 1.007±0.06 g/cm3(Predicted)
• PKA: 6.92±0.50(Predicted)
• CAS DataBase Reference: (Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine(78628-81-6)
• EPA Substance Registry System: (Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine(78628-81-6)

Safety Data

• Hazardous Substances Data: 78628-81-6(Hazardous Substances Data)

Usage

Uses

cis-Terbinafine is an impurity in the production of Terbinafine hydrochloride.

Upstream product

• 704909-67-1 (Z)-N-(3-chloro-2-propenyl)-N-methyl-1-naphthalenemethanamine 
• 917-92-0 3,3-Dimethylbut-1-yne 
• 134865-58-0 (2E)-3-chloro-N-methyl-N-(naphthalen-1-ylmethyl)prop-2-en-1-amine 
• 78628-80-5 terbinafine hydrochloride 
• 176168-78-8 N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethyl amine hydrochloride 
• 14489-75-9 N-methyl-1-naphthalenemethylamine 
• 78629-20-6 3-hydroxy-6,6-dimethylhept-1-ene-4-yne 
• 635708-74-6 (Z)-1-chloro-6,6-dimethylhept-2-en-4-yne 

Relevant articles and documents

Process for the preparation of terbinafine and salts thereof

A process for the preparation of Terbinafine and salts thereof by reacting 1-chloro-6,6-dimethylhept-2-en-4-yne and N-methyl-N-(1-naphthylmethyl)amine in a basic aqueous medium is disclosed. Also disclosed is a process for the preparation of 1-chloro-6,6-dimethylhept-2-en-4-yne.

PROCESS FOR PREPARING TERBINAFINE BY USING PLATINUM AS CATALYST

A process for the preparation of terbinafine, comprising the reaction of a compound of formula (II), or a salt thereof, wherein X is a leaving group, with tert-butylacetylene, in the presence of a platinum catalyst.