78633-44-0

Basic information

• Product Name: 2-Oxo-2,3-dihydro-benzooxazole-5-sulfonic acid (4-chloro-2-nitro-phenyl)-amide
• Synonyms: 2-Oxo-2,3-dihydro-benzooxazole-5-sulfonic acid (4-chloro-2-nitro-phenyl)-amide
• CAS NO: 78633-44-0
• Molecular Weight: 369.742
• Mol File: 78633-44-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Oxo-2,3-dihydro-benzooxazole-5-sulfonic acid (4-chloro-2-nitro-phenyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxo-2,3-dihydro-benzooxazole-5-sulfonic acid (4-chloro-2-nitro-phenyl)-amide(78633-44-0)
• EPA Substance Registry System: 2-Oxo-2,3-dihydro-benzooxazole-5-sulfonic acid (4-chloro-2-nitro-phenyl)-amide(78633-44-0)

Safety Data

• Hazardous Substances Data: 78633-44-0(Hazardous Substances Data)

Upstream product

• 78633-41-7 2-oxo-2,3-dihydro-1,3-benzoxazole-5-sulfonyl chloride 
• 89-63-4 4-Chloro-2-nitroaniline 

Downstream Products

• 94-97-3 5-chlorobenzotriazole 
• 78633-52-0 2-Oxo-2,3-dihydro-benzooxazole-5-sulfonic acid (2-amino-4-chloro-phenyl)-amide 

Relevant articles and documents

Benzoxazolone-5-sulphonanilides, 1-(benzoxazolone-5'-sulphonyl)-benzotriazoles and 4-hydroxy-3,2'-diaminobenzenesulphonanilides with antiviral activity

Benzoxazolone-5-(2'-nitro)-sulphonanilides were synthesized by acylation of o-nitroanilines with benzoxazolone-5-sulphochloride or 3-methylbenzoxazolone-5-sulphochloride. The nitro group in these compounds was subjected to reduction and the resulting amino derivatives were cyclysed to yield the corresponding 1-(benzoxazolone-5'-sulphonyl)-benzotriazoles. Decyclization of the oxazolone cycle of benzoxazolone-5-(2'-amino)-sulphonanilides resulted in 4-hydroxy-3,2'-diaminobenzenesulphonanilides. In vitro testing of the antiviral activity of the compounds obtained during successive synthetic steps revealed that some of them exhibited marked antiviral effect against toga, orthomixo, oncorna and herpes viruses.