78634-33-0

Upstream product

• 82255-66-1 1-Phenylbenzoisoquinolin-3(2H)-one 
• 132-75-2 naphthalen-1-ylacetonitrile 
• 100-52-7 benzaldehyde 
• 86-86-2 1-Naphthylacetamide 

Downstream Products

• 78634-30-7 4-Phenyl-3,4-dihydro-benzo[f]isoquinoline-1,2-dione 1-oxime 
• 82255-66-1 1-Phenylbenzoisoquinolin-3(2H)-one 
• 82255-76-3 4-Benzyl-1-phenyl-3-(2H)benzoisoquinolinone 

Relevant academic research and scientific papers

Novel Routes to 1-Aryl-1,4-dihydro-3(2H)-isoquinolinones and 2-Substituted or 2,3-Disubstituted Benzofurans by Intramolecular Cyclizations

N-(α-Benzotriazolylalkyl)arylacetamides, readily available from an arylacetamide, an aldehyde and benzotriazole, undergo intramolecular cyclization under acidic conditions to give 1-aryl-1,4-dihydro-3(2H)-isoquinolinones in good to excellent yields.Similarly, 2-(benzotriazol-1-yl)-2-(o-hydroxyphenyl)ethanols, obtained by lithiation of 2-(benzotriazol-1-ylmethyl)phenols followed by quenching with aldehydes or ketones, eliminate a molecule of water and a molecule of benzotriazole yielding 2-substituted and 2,3-disubstituted benzofurans.

Hydrogenation of Substituted 1-Arylisoquinolin-3(2H)-ones to 5,6,7,8-Tetrahydro- and 1,4-Dihydroisoquinolin-3(2H)-ones

Catalytic hydrogenation of variously substituted 1-arylisoquinolin-3(2H)-ones 1 gave, depending on the substituents, 5,6,7,8-tetrahydroisoquinolin-3(2H)-ones (2) and/or the corresponding 1,4-dihydro derivatives 3.Saturation of the compounds fused with ben