78635-91-3

Basic information

• Product Name: Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester
• Synonyms: Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester
• CAS NO: 78635-91-3
• Molecular Weight: 649.681
• Mol File: 78635-91-3.mol

Chemical Properties

• CAS DataBase Reference: Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester(78635-91-3)
• EPA Substance Registry System: Dimethyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester(78635-91-3)

Safety Data

• Hazardous Substances Data: 78635-91-3(Hazardous Substances Data)

Upstream product

• 2083-91-2 N,N-Dimethyltrimethylsilylamine 
• 86733-54-2 Phosphorous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester dimethyl ester 
• 17166-16-4 phosphorous acid tetramethyldiamide methylester 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 70063-12-6 Chloro-(N,N-dimethylamino)-methoxyphosphine 
• 86030-46-8 C₃₆H₄₂N₃O₉P 

Downstream Products

• 2476-56-4 5'-d(TpTp)-3' 
• 78635-99-1 C₄₇H₅₃N₄O₁₅P 
• 74855-51-9 Phosphorochloridous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester 
• 93134-47-5 C₅₁H₅₈N₇O₁₆P 
• 93134-45-3 C₄₇H₅₃N₄O₁₆P 

Relevant articles and documents

BIS-(N,N-DIALKYLAMINO)ALKOXYPHOSPHINES AS A NEW CLASS OF PHOSPHITE COUPLING AGENT FOR THE SYNTHESIS OF OLIGONUCLEOTIDES

A new class of bifunctional phosphitylating agent which is stable but readily activatable for the efficient synthesis of oligonucleotides is described.

Automatic synthesis of oligodeoxynucleotides and mixed oligodeoxynucleotides using the phosphoamidite method.

A simplified procedure for making and using the deoxynucleoside phosphoamidites (1 a-d) in the automated synthesis of oligodeoxynucleotides has been developed. The reagents prepared show good stability in solution. The reactivity of the reagents was found

A NEW AND GENERAL PROCEDURE FOR THE PREPARATION OF DEOXYNUCLEOSIDE PHOSPHORAMIDITES

Nucleoside phosphoramidites can be obtained in a one pot reaction by reacting successively an alkyloxy (or aryloxy)bis-triazolylphosphine with 3'-OH free deoxynucleoside and a trimethylsilylated secondary amine.

DEOXYNUCLEOSIDE PHOSPHORAMIDITES-A NEW CLASS OF KEY INTERMEDIATES FOR DEOXYPOLYNUCLEOTIDE SYNTHESIS

The development of a new class of nucleoside phosphites is described.These compounds are stable to normal laboratory conditions, are activated by mild acid treatment, and are observed to react essentially quantitatively with protected nucleosides.