78641-31-3Relevant academic research and scientific papers
Palladium-catalysed amination of halopyridines on a KF-alumina surface
Basu, Basudeb,Jha, Satadru,Mridha, Niranjan K.,Bhuiyan, Md. Mosharef H.
, p. 7967 - 7969 (2007/10/03)
Palladium-catalysed C-N hetero cross-coupling reactions between bromopyridines and amines (both primary and secondary) can be efficiently performed on a KF-alumina (basic) surface, thus negating the use of strong bases such as sodium tert-butoxide. The reaction conditions are optimised with reference to catalytic systems, solvents and the surface.
Synthesis and Chemical Properties of 3-Aminoquinoline
Schoenen, Beate,Zymalkowski, Felix
, p. 464 - 470 (2007/10/02)
Reaction of 3-bromoquinoline with ammonia gives 3-aminoquinoline (3) in good yield.Substitution of 3 is possible by treating the sodium salt of 3 with alkyl halides or by reductive alkylation with aromatic and aliphatic ketones.Amine exchange occurs by reaction of acetophenone Mannich bases with 3.Methyl vinyl ketone and acrylonitrile give no addition compounds with 3.Derivatives of trans-3-phenylglycidic acid react with 3 to give derivatives of β-phenylisoserine.
