78646-17-0

Usage

Uses

Used in Pharmaceutical Research:
2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard for various LC/MS and GC/MS applications in pharmaceutical research. It helps in the accurate quantification and identification of compounds, ensuring the reliability of the results.
Used in Clinical and Diagnostic Testing:
In the field of clinical and diagnostic testing, 2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard to improve the accuracy and precision of test results, leading to better diagnosis and treatment of various medical conditions.
Used in Phytochemical Testing:
2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard in phytochemical testing to analyze the chemical composition of plant extracts and identify bioactive compounds. This helps in the discovery of new drugs and understanding the pharmacological properties of plant-based medicines.
Used in Isotope Dilution Methods:
In isotope dilution methods, 2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard to accurately measure the concentration of target compounds in complex samples. This technique is widely used in environmental, forensic, and clinical chemistry for the determination of trace elements and contaminants.
Used in the Analysis of Acetylsalicylic Acid Impurities:
2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard for the analysis of impurities in Acetylsalicylic Acid (Aspirin), such as Labelled Salicylic Acid (S088125) and Labelled Acetylsalicylic Acid EP Impurity C. This helps in ensuring the quality and purity of the final product, which is crucial for its safety and efficacy.

InChI:InChI=1/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)/i1D,2D,3D,4D

Upstream product

• 69-72-7 salicylic acid 
• 97781-16-3 2-acetoxy<3,4,5,6-(2)H>benzoic acid 

Downstream Products

• 97781-16-3 2-acetoxy<3,4,5,6-(2)H>benzoic acid 

Relevant academic research and scientific papers

Efficient continuous-flow HD exchange reaction of aromatic nuclei in D2O/2-PrOH mixed solvent in a catalyst cartridge packed with platinum on carbon beads

Herein, a continuous-flow deuteration methodology for various aromatic compounds is developed based on heterogeneous platinum-catalyzed hydrogen-deuterium exchange. The reaction entails the transfer of a substrate dissolved in a mixed solvent of 2-propanol and deuterium oxide into a catalyst cartridge packed with platinum on carbon beads (Pt/CB). Pt/ CB could be continuously used without significant deterioration of catalyst activity for at least 24 h. Deuteration proceeded within 60 s of the substrate solutions being passed through the Pt/CB layer in the Pt/CB-packed cartridge.

H-D Exchange Deuteration of Arenes at Room Temperature

Arene nuclei efficiently underwent the hydrogen (H)-deuterium (D) exchange reaction catalyzed by platinum group metals on carbon in a mixed solvent of 2-propanol and D2O at room temperature to produce deuterium-labeled arenes. Platinum on carbon (Pt/C) and iridium on carbon (Ir/C) were applicable catalysts, and the various arenes bearing a carbonyl group, fluorine, phenolic hydroxy group, amino group, or phosphonic acid on the aromatic nucleus were effectively deuterated. Nonheating conditions are valuable for the scalable industrial preparation.

Preparation and analysis of deuterium-labeled aspirin: Application to pharmacokinetic studies

Inhibition of endogenous prostacyclin and thromboxane biosynthesis by aspirin is critically dose-dependent in humans. Gastrointestinal and hepatic hydrolysis may limit systemic availability of aspirin, especially in low doses, perhaps contributing to the