97781-16-3 Usage
Description
Aspirin-d4 is intended for use as an internal standard for the quantification of aspirin by GC- or LC-MS. Aspirin is a non-selective, irreversible COX inhibitor. The IC50 values for ovine COX-1 and -2 are 0.75 and 1.25 mM, respectively. Aspirin acetylates COX-1 at Ser530 and COX-2 at Ser516 resulting in irreversible enzyme inhibition.
Chemical Properties
2-ACETOXYBENZOIC-3,4,5,6-D4 ACID is Off-White Solid
Uses
Labeled Aspirin, intended for use as an internal standard for the quantification of Aspirin by GC- or LC-mass spectrometry.
Check Digit Verification of cas no
The CAS Registry Mumber 97781-16-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,7,7,8 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 97781-16:
(7*9)+(6*7)+(5*7)+(4*8)+(3*1)+(2*1)+(1*6)=183
183 % 10 = 3
So 97781-16-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)/i2D,3D,4D,5D
97781-16-3Relevant articles and documents
Efficient continuous-flow HD exchange reaction of aromatic nuclei in D2O/2-PrOH mixed solvent in a catalyst cartridge packed with platinum on carbon beads
Park, Kwihwan,Ito, Naoya,Yamada, Tsuyoshi,Sajiki, Hironao
supporting information, p. 600 - 605 (2021/03/29)
Herein, a continuous-flow deuteration methodology for various aromatic compounds is developed based on heterogeneous platinum-catalyzed hydrogen-deuterium exchange. The reaction entails the transfer of a substrate dissolved in a mixed solvent of 2-propanol and deuterium oxide into a catalyst cartridge packed with platinum on carbon beads (Pt/CB). Pt/ CB could be continuously used without significant deterioration of catalyst activity for at least 24 h. Deuteration proceeded within 60 s of the substrate solutions being passed through the Pt/CB layer in the Pt/CB-packed cartridge.
