786595-16-2Relevant academic research and scientific papers
A facile synthesis for novel loperamide analogs as potential μ opioid receptor agonists
Bao, Xiaofeng,Liu, Duliang,Jin, Yanyan,Yang, Yao
, p. 14288 - 14297 (2013/02/25)
A facile synthesis for novel loperamide analogs as potential μ opioid receptors is described. The synthetic procedure for compound 5, which contains two 4-phenyl piperidine scaffolds, was optimized, and this compound was synthesized in excellent yield. We
Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor
Chen, Zhengming,Davies, Ellen,Miller, Wendy S.,Shan, Shen,Valenzano, Kenneth J.,Kyle, Donald J.
, p. 5275 - 5279 (2007/10/03)
Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series. Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series.
