786695-87-2

Upstream product

• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 786695-44-1 (2S,4R,6R)-2-((E)-styryl)-6-vinyltetrahydro-2H-pyran-4-ol 
• 100-42-5 styrene 
• 89858-82-2 endo-8-oxabicyclo[3.2.1]oct-6-en-3-ol 

Downstream Products

• 786695-88-3 (2R,4R,6S)-tetrahydro-2-(2-hydroxyethyl)-4-(triisopropylsilyloxy)-6-(E)-styryl-2H-pyran 
• 529494-87-9 (2S,4R,6R)-tetrahydro-2-hydroxymethyl-4-(triisopropylsilyloxy)-6-[2-(4-methoxybenzyloxy)ethyl]-2H-pyran 
• 786695-89-4 (2S,4R,6R)-tetrahydro-4-(triisopropylsilyloxy)-2-[2-(4-methoxybenzyloxy)ethyl]-6-(E)-styryl-2H-pyran 

Relevant academic research and scientific papers

Efficient enantioselective synthesis of functionalized tetrahydropyrans by Ru-catalyzed asymmetric ring-opening metathesis/cross-metathesis (AROM/CM)

An efficient method for enantioselective synthesis of highly functionalized pyrans (up to 98% ee) through Ru-catalyzed asymmetric ring-opening metathesis/cross-metathesis is described. Reactions are promoted by a recyclable chiral Ru-chloride or a new chiral Ru-iodide complex; the latter catalyst is less efficient but gives rise to significantly higher levels of enantioselectivity. Catalytic reactions can be performed in undistilled solvent and with a wide range of substrates, including those that contain secondary and tertiary alcohols. Representative regioselective functionalizations that highlight the utility of the catalytic method are also presented. Copyright