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Amicoumacins are a group of glycopeptide antibiotics that are closely related to vancomycin. They are produced by certain strains of the actinomycete Amycolatopsis and are known for their potent activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Amicoumacin A, in particular, is characterized by its ability to inhibit cell wall synthesis in bacteria, leading to cell death. It is composed of a complex structure that includes a heptapeptide chain attached to a disaccharide moiety. The antibiotic's mechanism of action involves binding to the D-Ala-D-Ala terminal of peptidoglycan precursors, thereby preventing the cross-linking process essential for bacterial cell wall integrity. Amicoumacin A's unique structure and activity make it a valuable compound in the fight against antibiotic-resistant infections, although its use is limited due to potential nephrotoxicity.

78683-77-9

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78683-77-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 78683-77-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,6,8 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78683-77:
(7*7)+(6*8)+(5*6)+(4*8)+(3*3)+(2*7)+(1*7)=189
189 % 10 = 9
So 78683-77-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H29N3O7.ClH/c1-9(2)6-12(23-19(28)18(27)17(26)11(21)8-15(22)25)14-7-10-4-3-5-13(24)16(10)20(29)30-14;/h3-5,9,11-12,14,17-18,24,26-27H,6-8,21H2,1-2H3,(H2,22,25)(H,23,28);1H

78683-77-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-amino-2,3-dihydroxy-N-[1-(8-hydroxy-1-oxo-3,4-dihydroisochromen-3-yl)-3-methylbutyl]hexanediamide,hydrochloride

1.2 Other means of identification

Product number -
Other names AC1L4Y8C

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78683-77-9 SDS

78683-77-9Downstream Products

78683-77-9Relevant academic research and scientific papers

1H-2-Benzopyran-1-one Derivatives, Microbial Products with Pharmacological Activity. Relationship between Structure and Activity in 6-amino>-4(S),5(S)-dihydroxy-6-oxo-3(S)-ammonioh

Shimojima, Yukiji,Hayashi, Hiroshi

, p. 1370 - 1374 (2007/10/02)

In order to investigate the structural requirements for gastroprotective activity in 6-amino>-4(S),5(S)-dihydroxy-6-oxo-3(S)-ammoniohexanoate , a product of Bacillus pu

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