38076-80-1

Basic information

• Product Name: 5-Chloro-2-hydroxynicotinic acid
• Synonyms: BUTTPARK 43\57-84;5-CHLORO-2-HYDROXYNICOTINIC ACID;5-CHLORO-2-HYDROXYPYRIDINE-3-CARBOXYLIC ACID;5-chloro-2-hydroxy-3-pyridinecarboxylic acid;clioqinol;5-Chloro-2-hydroxynicotinic acid 97+%;5-chloro-2-hydroxynicotinic;5-Chloro-2-hydroxypyridine-3-carboxylic acid, 3-Carboxy-5-chloro-2-hydroxypyridine
• CAS NO: 38076-80-1
• Molecular Formula: C₆H₄ClNO₃
• Molecular Weight: 173.55
• Product Categories: Pyridine
• Mol File: 38076-80-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 260 °C
• Boiling Point: 343.8 °C at 760 mmHg
• Flash Point: 161.7 °C
• Appearance: Solid
• Density: 1.62 g/cm³
• Vapor Pressure: 1.23E-05mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 5-Chloro-2-hydroxynicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-hydroxynicotinic acid(38076-80-1)
• EPA Substance Registry System: 5-Chloro-2-hydroxynicotinic acid(38076-80-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 38076-80-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 19, p. 553, 1989 DOI: 10.1080/00397918908050699

InChI:InChI=1/C6H4ClNO3/c7-3-1-4(6(10)11)5(9)8-2-3/h1-2H,(H,8,9)(H,10,11)/p-1

Upstream product

• 609-71-2 2-hydroxy-3-carboxypyridine 
• 108-20-3 di-isopropyl ether 
• 5437-33-2 3,5-Dichloro-2-pyridinol 

Downstream Products

• 882679-04-1 methyl 5-chloro-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate 
• 67754-03-4 methyl 2,5-dichloronicotinate 
• 148065-10-5 ethyl 5-chloro-2-chloronicotinate 
• 648421-99-2 5-chloro-3-[(3-methyl-1-piperidinyl)carbonyl]-2-pyridinol 
• 157361-96-1 methyl-5-chloro-2-propylaminonicotinate 
• 78686-87-0 2,5-dichloronicotinoyl chloride 
• 59782-85-3 2,5-dichloronicotinic acid 

Relevant articles and documents

SUBSTITUTED NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES

Inhibitors of MIF having a naphthyridine backbone are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: (Ia), (Ib), (Ic), (Id) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R, R1, R2, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

Process for the preparation of 5-chloro and 5-bromo-2-hydroxynicotinic acids

A process for the preparation of 5-halo-2-hydroxynicotinic acids having the formula: STR1 wherein X is chlorine or bromine, Y and Z are selected from hydrogen, loweralkyl or loweralkyl, is described wherein a corresponding 2-hydroxynicotinic acid is halogenated with alkali-metal hypohalite in a strongly alkaline solution pH 12 and above. Certain aspects of the isolation of the product are directed to avoiding replacement of the carboxy group with halogen.