78701-70-9

Upstream product

• 78701-69-6 3-(ethoxycarbonyl)-4-(2-phenylethyl)-5-<(phenylmethoxy)carbonyl>-1H-pyrrole-2-acetic acid, ethyl ester 
• 77-78-1 dimethyl sulfate 
• 62282-45-5 benzyl 3-oxo-5-phenylpentanoate 
• 17071-29-3 ethyl 3-oxo-5-phenylpentanoate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 78702-09-7 5-carboxy-3-(ethoxycarbonyl)-1-methyl-4-(2-phenylethyl)-1H-pyrrole-2-acetic acid, ethyl ester 
• 87885-85-6 5-Chlorocarbonyl-2-ethoxycarbonylmethyl-1-methyl-4-phenethyl-1H-pyrrole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

10 Oxo-4,5-dihydro-10H-benzo 5,6 cycloheph[1,2-B]pyrryls

A compound of formula (II): STR1 wherein R is a C1-4 alkyl group; R1 is a hydrogen atom or a C1-4 alkyl group; R2 is a hydrogen or halogen atom, or a C1-4 alkyl, C1-4 alkoxy or C1-4 alkylthio group; and pro-drugs thereof; and the pharmaceutically acceptable salts of the compounds of formula (II) and of their pro-drugs; has useful anti-inflammatory and analgesic activity.

4,5,8,9-Tetrahydro-8-methyl-9-oxothieno[3',2':5,6]cyclohepta[1,2-b]- pyrrole-7-acetic acid (1). A new anti-inflammatory/analgesic agent

The synthesis of the thienocyclohepta[1,2-b]pyrrole acid 1 from the morpholide 3 is reported. This novel morpholide was prepared by regiospecific alkylation of the dianion of 4-(1,3-dioxobutyl)morpholine with 3-bromomethylthiophene. Subsequent Knorr pyrro