62282-45-5Relevant academic research and scientific papers
Oxone-promoted hydration of electron-deficient allenic esters and ketones into 1,3-dicarbonyl compounds
Yi, Yu-Ping,Zheng, Yan,Nie, Jing,Ma, Jun-An
, p. 4523 - 4526 (2015/06/30)
Abstract A novel and mild protocol for the hydration of electron-deficient allenic esters and ketones into various 1,3-dicarbonyl compounds is described. The hydration of allenes promoted by oxone in DMF afforded the corresponding products in moderate to good yields. This work features the employment of only a catalytic amount of inexpensive and nontoxic solid reagent oxone (2KHSO5·KHSO4·K2SO4), avoiding the utility of toxic metals or traditional Br?nsted acids, in a green version of viewpoint. A possible reaction mechanism for this transformation is also primarily proposed.
10 Oxo-4,5-dihydro-10H-benzo 5,6 cycloheph[1,2-B]pyrryls
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, (2008/06/13)
A compound of formula (II): STR1 wherein R is a C1-4 alkyl group; R1 is a hydrogen atom or a C1-4 alkyl group; R2 is a hydrogen or halogen atom, or a C1-4 alkyl, C1-4 alkoxy or C1-4 alkylthio group; and pro-drugs thereof; and the pharmaceutically acceptable salts of the compounds of formula (II) and of their pro-drugs; has useful anti-inflammatory and analgesic activity.
4,5,8,9-Tetrahydro-8-methyl-9-oxothieno[3',2':5,6]cyclohepta[1,2-b]- pyrrole-7-acetic acid (1). A new anti-inflammatory/analgesic agent
Goudie,Rosenberg,Ward
, p. 1027 - 1030 (2007/10/02)
The synthesis of the thienocyclohepta[1,2-b]pyrrole acid 1 from the morpholide 3 is reported. This novel morpholide was prepared by regiospecific alkylation of the dianion of 4-(1,3-dioxobutyl)morpholine with 3-bromomethylthiophene. Subsequent Knorr pyrro
