78702-84-8

Upstream product

• 84344-44-5 1-(3-nitrophenoxy)-3-1-(N⁴-phenylpiperazinyl)>propane 
• 92-54-6 4-phenyl-1-piperazine 
• 108-24-7 acetic anhydride 
• 85868-45-7 1-(3-aminophenoxy)-3-1-(N⁴-phenylpiperazinyl)>propane 
• 10599-17-4 1-(3-chloropropyl)-4-phenylpiperazine 
• 621-42-1 meta-hydroxyacetanilide 

Downstream Products

• 78702-83-7 N-{3-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-phenyl}-formamide 
• 114614-34-5 N-methyl-3-<3-(4-phenyl-1-piperazinyl)propoxy>benzenamine 
• 85868-45-7 1-(3-aminophenoxy)-3-1-(N⁴-phenylpiperazinyl)>propane 

Relevant academic research and scientific papers

Dopamine Autoreceptor Agonists as Potential Antipsychotics. 1. (Aminoalkoxy)anilines

The synthesis and pharmacological properties of a novel type of anilines with dopaminergic properties are described.One of these compounds, 3-benzeneamine (4c), has been identified as a selective

Synthesis and Structure Activity Relationship in 1-(Substituted aminophenoxy)-3-1-(N4-arylpiperazinyl)>propanes

1-(Aminophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (1-8) have been prepared by the catalytic hydrogenation of 1-(nitrophenoxy)-3-1-(N4-arylpiperazinyl)>propanes.The reaction of aminophenoxypiperazinylpropanes (1-8) with acetic anhydride gives the corresponding 1-(acetamidophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (9-15) and with methanesulphonyl chloride the corresponding 1-(methanesulfonamidophenoxy)-3-1-(N4-arylpiperazinyl)>propanes (16-19) are obtained.The amino compounds (3 and 4) on treatment with lactim thioethers and isocyanates/isothiocanates afford the corresponding 1-- (20-30) and 1-(ureido/thioureidophenoxy)-3-1-(N44-arylpiperazinyl)>propanes (31-37).Some of these compunds show potent CNS depressant, hypotensive, α-adrenoceptor blocking, antiinflammatory and diuretic activities.Among these compounds 1-(4-aminophenoxy)-3-1-(N4-(2-methoxyphenyl)piperazinyl)>propane (4) is found to be potent neuroleptic.