78721-55-8

Basic information

• Product Name: N-(4-nitrophenyl)-4-phenylpiperazine-1-carbothioamide
• Synonyms: N-(4-nitrophenyl)-4-phenylpiperazine-1-carbothioamide
• CAS NO: 78721-55-8
• Molecular Weight: 342.422
• Mol File: 78721-55-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-nitrophenyl)-4-phenylpiperazine-1-carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-nitrophenyl)-4-phenylpiperazine-1-carbothioamide(78721-55-8)
• EPA Substance Registry System: N-(4-nitrophenyl)-4-phenylpiperazine-1-carbothioamide(78721-55-8)

Safety Data

• Hazardous Substances Data: 78721-55-8(Hazardous Substances Data)

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 2131-61-5 p-nitrophenyl isothiocyanate 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 78721-75-2 N-(4-isothiocyanatophenyl)-1-phenyl-4-piperazinylcarboxamide 
• 78721-69-4 4-Phenyl-piperazine-1-carbothioic acid (4-amino-phenyl)-amide 

Relevant articles and documents

Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening

USP8, one member of deubiquitinating enzymes (DUBs) families, maintains the ubiquitination level of EGFR and regulates the downstream signaling pathways. The deregulation of USP8 has been implicated in many human diseases, especially in cancer. Therefore, USP8 has been identified as a promising target for drug design. Herein, via high throughput screening based on Ubiquitin-rhodamine-110 (Ubiquitin-Rho-110) fluorometric activity assay, we discovered a novel inhibitor DC-U43. By structure optimization, DC-U43-10 reached a half-maximal inhibitory concentration (IC50) value of 2.6 ± 1.1 μM and exhibited 10-fold selectivity against USP7. The binding between DC-U43-10 and USP8 was validated by surface plasmon resonance (SPR) assay with a KD value of 10.5 ± 3.7 μM. It also inhibited the colony formation of H1975 cells. Hence, DC-U43-10 represents a kind of USP8 inhibitors with novel scaffold and has broad prospects for being a probe for USP8-related academic and clinical research.

Synthesis of Substituted Thiocarboxamides, Carboxamides and Thioureas as Potential Anthelmintic and Antimicrobial Agents

A series of substituted thiocarboxamides (6-26), carboxamides (27-32), thioureas (33-37) and urea (38) have been synthesized starting from various aryl isothiocyanates (1-5).Their anthelmintic and antimicrobial activities are reported.Of these 8 and 9 show 60-70percent reduction in worms at a dose of 100-250 mg/kg given for three days.