78735-39-4Relevant academic research and scientific papers
Thiol-Ene click reactions - Versatile tools for the modification of unsaturated amino acids and peptides
Karmann, Lisa,Kazmaier, Uli
, p. 7101 - 7109 (2013)
Terminal γ,δ-unsaturated amino acids, easily available by Claisen rearrangement or palladium-catalysed allylic alkylation, are excellent substrates for radical thiol additions. These click reactions allow the introduction of highly functionalized side-chains into a given amino acid or peptide. This protocol is suitable for the modification of all kinds of terminal alkenes, such as allyl protecting groups. Terminal γ,δ-unsaturated amino acids and peptides, easily available by Claisen rearrangement or palladium-catalysed allylic alkylation, are excellent substrates for radical thiol additions. These click reactions allow the introduction of highly functionalized side-chains into a given amino acid or peptide. This protocol is also suitable for the modification of allyl protecting groups. Copyright
CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR
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Paragraph 0270; 0273-0274, (2021/11/26)
The present invention relates to a novel molecule with protein tyrosine kinase inhibitory activity, and the synthesis and usage thereof. Specifically, the present invention relates to compound by formula A, pharmaceutically acceptable salts, hydrates or solvates thereof, and the synthesis and usage thereof.
