78742-25-3Relevant academic research and scientific papers
Synthesis, Reactions, and Molecular Structures of Ethylzinc Enolates of Chiral N-Substituted β-Carbonyl Sulfoximines
Bolm, Carsten,Mueller, Juergen,Zehnder, Margareta,Neuburger, Markus A.
, p. 312 - 317 (2007/10/02)
The preparation, structural characterization, and reactivity of ethylzinc-containing enolates and organometallics derived from β-carbonyl sulfoximines are reported.X-ray crystal structures show significant differences between aggregated species obtained f
Diastereoselective Reductions of β-Keto Sulfoximines
Johnson, Carl R.,Stark, Charles J.
, p. 1196 - 1200 (2007/10/02)
(S)-β-Keto sulfoximines have been prepared by butyllithium-mediated condensation of (+)-(S)-N,S-dimethyl-S-phenylsulfoximine with nitriles.The β-keto sulfoximines on treatment with a variety of reducing agents afforded β-hydroxy sulfoximines with varying diastereomeric ratios.Highest asymmetric inductions were observed with gaseous diborane.A sulfoximine-borane complex is suggested as an intermediate.Raney nickel desulfurization of the β-hydroxy sulfoximines afforded secondary alcohols with optical purities in the 18-69percent range.
