78752-50-8Relevant articles and documents
Static Retention of Dynamic Chiral Arrangements for Achiral Shear Thinning Metal–Organic Colloids
Huang, Jian-Cai,Xiao, Hui,Chen, Zhixin,Zheng, Wenxu,Huang, Chang-Cang,Wu, Shu-Ting,Xie, Zenghong,Zhuang, Naifeng
, p. 14017 - 14024 (2021/09/02)
Chiral compounds are known to be important not only because they are the fundamental components of living organisms, but also for their unique chiroptical properties. In recent years, scientists have fabricated several chiral organic supramolecular aggregates by using chiral physical fields, such as vortex flow. Herein, the relationship between dynamic chiroptical properties and rheological nature is discussed, suggesting the shear thinning properties of non-Newtonian fluids might help colloidal particles adopt a chiral arrangement in vortices. Furthermore, the storage modulus of colloids could be increased by adding a linking agent, which successfully kept the dynamic chiroptical properties in the static state. Moreover, the salt effect on the host–guest interaction involved in the colloids was studied, the results suggested a significant enhancement of the transferred dynamic circular dichroism for the achiral guest molecule.
Colorant with double catechol structure, preparation method and applications thereof
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Paragraph 0108; 0113-0114, (2020/05/30)
The invention relates to the technical field of organic colorants, and particularly provides a colorant with a double catechol structure, a preparation method and applications thereof, wherein the colorant has a structural general formula represented by a
Unraveling the Self-Assembly of Heterocluster Janus Dumbbells into Hybrid Cubosomes with Internal Double-Diamond Structure
Liu, Hong-Kai,Ren, Li-Jun,Wu, Han,Ma, Yong-Li,Richter, Sven,Godehardt, Michael,Kübel, Christian,Wang, Wei
, p. 831 - 839 (2019/01/23)
Cubosomes are bicontinuous cubic-phase particles generated by amphiphile self-assembly with bicontinuous cubic phases, which creates an intricate network of interconnected nanochannels that endow these materials with special functions for advanced applications. On the other hand, clusters are an attractive class of molecules that exhibit intriguing functions and properties that differ from those of atoms and nanoparticles. Inspired by lipid self-assembly and attracted to the new functionalities of clusters, we prepared special heterocluster Janus dumbbells (HCJDs) composed of dissimilar nanoclusters: namely, a polyoxometalate and a polyhedral oligomeric silsesquioxane. HCJDs resemble conventional amphiphiles and, as such, they self-assemble in solution into faceted hybrid cubosomes via the transformation of vesicles into spongelike aggregates. Multiple mechanisms that lead to equilibrium, including molecular self-assembly, vesicle accumulation, membrane fusion, inner-structure reorganization, and cubic crystal growth, contributed to the overall process. On the basis of these results, we proposed a strategy for self-assembly - from basic molecular design that goes beyond traditional amphiphiles to the construction of micro- or nanomaterials with hierarchical structures and advanced functions.
Synthesis and characterization of ferrocenyl esters: Their anti-oxidant activity and DNA-binding ability
Bukhari, Syeda Anam,Gul, Asghari,Akhter, Zareen,Bashir, Amna
, p. 375 - 382 (2018/06/06)
In continuation to our work on biologically active material, some new ferrocenyl esters were prepared by condensation of 4-ferrocenyl phenol (ROH) with ferrocenyl dicarboxylic acid chlorides (DCC) at low temperature. The synthesized compounds (E1-E9) were characterized by analyzing their physical properties, FT-IR, 1H-NMR, UV-visible spectroscopic and cyclic voltammetric studies. The DPPH free radical scavenging assay was performed to explore their potential as antioxidant which showed that the E1 had maximum scavenging ability (77.11%) whereas E3 showed minimum (52%) compared with the standard. Cyclic voltammetric studies indicated that these compounds were electroactive in potential window of 2.0-0.0V. Binding mode found in these esters was an electrostatic interaction which is considered as strongest amongst all. Therefore, these compounds are considered to have DNA-binding capability and are potential DNA binders.
Multistate Photoswitches: Macrocyclic Dihydroazulene/Azobenzene Conjugates
Vlasceanu, Alexandru,Koerstz, Mads,Skov, Anders B.,Mikkelsen, Kurt V.,Nielsen, Mogens Br?ndsted
supporting information, p. 6069 - 6072 (2018/04/30)
Molecules comprised of three covalently linked bi-stable switches can exist in states described by a combination of binary numbers, one for each individual switch: ?000?, ?001?, etc. Here we have linked three photo-/thermoswitches together in a rigid macrocyclic structure, one azobenzene (bit no 1) and two dihydroazulenes (DHAs; bits no 2 and 3) and demonstrate how electronic interactions and unfavorable strain in some states can be used to control the speed by which a certain state is reached. More specifically, upon irradiation of state ?000?, the AZB isomerizes from trans to cis and the two DHAs to vinylheptafulvenes (VHFs), generating ?111?. The thermal VHF-to-DHA back-reactions from this state also occur stepwise and can be accelerated by photo-induced AZB cis-to-trans conversion, proceeding via ?011? to ultimately furnish ?000?. Overall, the accessibility to a specific state of one bit was found to depend on the states of its neighboring bits.
Synthesis and self-assembly of photoresponsive and luminescent polycatenar liquid crystals incorporating an azobenzene unit interconnecting two 1,3,4-thiadiazoles
Peng, Xiongwei,Gao, Hongfei,Xiao, Yulong,Cheng, Huifang,Huang, Fanran,Cheng, Xiaohong
, p. 2004 - 2012 (2017/03/10)
Novel polycatenar liquid crystals containing two 1,3,4-thiadiazole rings interconnected by an azobenzene central linkage have been synthesized and investigated by polarizing microscopy, DSC, X-ray scattering, SEM, UV-vis spectroscopy and photoluminescence measurements. These compounds can self-assemble into SmC, Colhex/p6mm and CubI/Pm3n liquid crystalline phases in the bulk states and form multistimuli responsive organogels in organic solvents. They have reversible photoresponsive properties in solution, liquid crystalline states and gel states. They also show fluorescence emission with large Stokes shift in solution and binding selectivity to Cu2+ among a series of cations in CH3CN-CH2Cl2 solution.
Hypoxia-responsive drug–drug conjugated nanoparticles for breast cancer synergistic therapy
Zhang, Ruilong,Li, Yan,Zhang, Miao,Tang, Qunwei,Zhang, Xin
, p. 30268 - 30276 (2019/01/14)
In order to eliminate tumors, it is necessary to kill differentiated cancer cells, cancer stem cells (CSCs) and the “vascular niche” synergistically. Although nanoparticles (NPs) have been used to deliver drugs to the action sites, inert materials with high toxicity may reduce the drug loading content and cause side-effects to kidneys and other organs in the course of degradation and excretion. Here, we report hypoxia-responsive drug–drug conjugated NPs to deliver three drugs to kill differentiated cancer cells, CSCs and the “vascular niche” synergistically, which could selectively release the drugs to treat cells in hypoxic tumors. For this purpose, an azobenzene (AZO) bond imparting hypoxia sensitivity and specificity as a crosslinker conjugated hydrophobic combretastatin A-4 (CA4) with hydrophilic irinotecan (IR) to form IR–AZO–CA4 amphiphilic molecules. These molecules self-assembled into NPs, which could encapsulate hydrophobic anti-CSCs drug cyclopamine (CP). The drug–drug conjugated NPs had high drug loading content. As expected, the AZO linker could be broken under hypoxia conditions and the NPs were disassembled to release drugs quickly. Confocal laser scanning microscopy (CLSM) results indicated that the IR–AZO–CA4/CP NPs could enhance the cellular uptake of drugs and the permeability of drugs to the inner of CSCs, beneficial for tumor therapy. Furthermore, the IR–AZO–CA4/CP NPs could inhibit the migration, invasion and mammosphere formation capacity of CSCs. More importantly, only IR–AZO–CA4/CP NPs could simultaneously inhibit differentiated cancer cells, CSCs and endothelial cells without interference on the cell under a normoxic environment. The present study suggests that the IR–AZO–CA4/CP NPs provide a promising therapeutic approach for anticancer treatment.
Novel Carbazole (Cbz)-Based Carboxylated Functional Monomers: Design, Synthesis, and Characterization
Mondal, Ejabul,Lellouche, Jean-Paul,Naddaka, Maria
, p. 489 - 496 (2015/10/05)
A series of novel functional carbazole (Cbz)-based carboxylated monomers were synthesized and characterized. A Clauson-Kaas procedure, a deprotection step, amide coupling, and hydrolysis were utilized as key chemical reactions towards the multistep synthesis of monomers in good to excellent isolated yields. The design strategy was further extended to complex carbazole-COOH monomers incorporated arylazo groups as photoreactive moieties. In addition, photoreactive hybrid carbazole (Cbz)-pyrrole (Pyr)-based carboxylated monomers, comprising a pyrrole core linking a carbazole and a photoreactive phenylazide or benzophenone moiety through an amide spacer in the molecular structure, were also synthesized. The latter can be utilized for surface modification of polymeric films in their monomeric form or as polymeric microparticles (MPs). Functional monomers: Novel functional carbazole-based carboxylated monomers were accessed using a Clauson-Kaas procedure, a deprotection step, amide coupling, and hydrolysis in a multistep synthesis. The design strategy was extended to complex carbazole-COOH monomers incorporating arylazo and phenylazide or benzophenone as photoreactive moieties, which can be utilized for functionalization/decoration of various polymeric and non-polymeric surfaces, matrices, and non-functional nanomaterials in their monomeric states or as polymeric microparticles (MPs).
Development of hypoxia-triggered prodrug micelles as doxorubicin carriers for tumor therapy
Liu, Hongmei,Zhang, Ruilong,Niu, Yunwei,Li, Yan,Qiao, Chenmeng,Weng, Jie,Li, Jun,Zhang, Xiaoning,Xiao, Zuobing,Zhang, Xin
, p. 20848 - 20857 (2015/03/18)
Hypoxia has a major role in tumor development and resistance to therapy. Therefore, the effective targeting and killing of hypoxic tumor cells is a key to successful tumor control. Here, we report the hypoxia-responsive prodrug micelles to deliver hydrophobic anticancer drug, which can selectively release the drugs to treat hypoxic tumor cells in a combined way. For this purpose, an azobenzene (AZO) bond, which imparts hypoxia sensitivity and specificity as cross linker, conjugated PEG-hexanethiol (PEG-C6) with combretastatin A-4 (CA4) to form PEG-C6-AZO-CA4 amphiphilic molecule. These PEG-C6-AZO-CA4 molecules self-assemble into micelles, which can encapsulate hydrophobic anticancer drug. The drug release behavior from PEG-C6-AZO-CA4 micelles was studied under normoxic or hypoxic conditions and the combinations of CA4 with hydrophobic drugs for tumor treatment in vitro were also investigated. As the first example of using AZO linkages to develop anticancer prodrug micelles as hydrophobic anticancer drugs delivery to kill the hypoxic tumor cells in a combination way, this study establishes PEG-C6-AZO-CA4 micelles as a promising drug delivery platform for hypoxic tumor therapy. This journal is
Synthesis, crystal structure and Cu2+ recognition of novel azobenzene derivatives
Wang, Wei,Li, Mingzhu,Yu, Xiaolong,Zhang, Qiang,Jiang, Xiaoyu,Wang, Junwu,Gao, Yan
, p. 98 - 101 (2014/03/21)
Three novel azobenzene derivatives have been synthesised from (E)-4,4′-bischloroformyl azobenzene and arylamines. The crystal structure of (E)-[{diazene-1,2-diylbis(4,1-phenylene)}bis{(3,5-dimethyl-1H-pyrazol-1-yl) methanone}] has been obtained The UV-Vis
