78755-03-0

Basic information

• Product Name: 1-phenyl-3-(2-pyridyl)thiobarbiturate
• CAS NO: 78755-03-0
• Molecular Weight: 297.337
• Mol File: 78755-03-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-phenyl-3-(2-pyridyl)thiobarbiturate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-(2-pyridyl)thiobarbiturate(78755-03-0)
• EPA Substance Registry System: 1-phenyl-3-(2-pyridyl)thiobarbiturate(78755-03-0)

Safety Data

• Hazardous Substances Data: 78755-03-0(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 504-29-0 2-aminopyridine 
• 886-60-2 1-(2'-pyridyl)-3-phenylthiourea 
• 141-82-2 malonic acid 

Downstream Products

• 156338-82-8 5-[(4-Chloro-phenylamino)-methyl]-1-phenyl-3-pyridin-2-yl-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 156338-78-2 5-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-1-phenyl-3-pyridin-2-yl-2-thioxo-dihydro-pyrimidine-4,6-dione 

Relevant articles and documents

Anticonvulsant activity and succinate dehydrogenase inhibitory property of new substituted thiobarbiturates

Eight 1-aryl-3-(2-pyridyl)thiobarbiturates were synthesized and evaluated for their anticonvulsant property and their ability to inhibit succinate dehydrogenase activity of rat brain homogenates. These substituted thiobarbiturates (100 mg./kg., i.p.) provided 20-60% protection against pentylenetetrazol-induced convulsions in albino mice. Low toxicity of these compounds was reflected by their high approximate LD50 values which were found to range from 500-1000 mg/kg. All substituted thiobarbiturates (1mM) inhibited in vitro succinate dehydrogenase activity and the degree of inhibition ranged from 10-72%.