78755-91-6

Basic information

• Product Name: ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• Synonyms: ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• CAS NO: 78755-91-6
• Molecular Weight: 421.453
• Mol File: 78755-91-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate(78755-91-6)
• EPA Substance Registry System: ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate(78755-91-6)

Safety Data

• Hazardous Substances Data: 78755-91-6(Hazardous Substances Data)

Upstream product

• 78756-02-2 3,4-dihydro-4-(2,4-dimethoxybenzyl)-1H-1,4-benzodiazepine-2,5-dione 
• 428507-28-2 (E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester 
• 2999-46-4 Ethyl isocyanoacetate 
• 865-47-4 potassium tert-butylate 
• 814-49-3 diethyl chlorophosphate 
• 613-45-6 2,4-Dimethoxybenzaldehyde 

Relevant articles and documents

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series

Through iterative design cycles we have discovered a number of novel new classes where the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine was deemed the most promising GABAA α5 inverse agonist class with potential for cognitive enhanc

Imidazodiazepine derivatives

Imidazodiazepine derivatives of the formula STR1 wherein A together with the two carbon atoms denoted as α and β is selected from the group consisting of STR2 the dotted line represents the double bond present in groups (a) and (b), D is >C O or >C S, R 1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR 4, R 4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R 5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R 6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R 2 is hydrogen and R 3 is hydrogen or lower alkyl or R 2 and R 3 together are trimethylene or propenylene and the carbon atom denoted as γ has the S- or R,S-configuration, and pharmaceutically acceptable salts thereof are presented and have utility for antagonizing the central-depressant, muscle relaxant, ataxic, blood pressure-lowering and respiratory-depressant properties of 1,4-benzodiazepines which have tranquillizing activity. They can be used, for example, as antidotes in the case of intoxications in which excessive intake of 1,4-benzodiazepines which have tranquillizing participates, or for shortening an anaesthesia induced by such 1,4-benzodiazepines. They can also be used for suppressing the activities on the central nervous system of 1,4-benzodiazepines used in other fields of indication, for example of schistosomicidally-active 1,4-benzodiazepines such as (+)-5-(o-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-2H-1,4-benzodiazepin-2-one.Also presented are processes to produce the imidazodiazepine derivatives and intermediates therefor.