78756-03-3

Basic information

• Product Name: ethyl 5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• Synonyms: 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 5,6-dihydro-5-methyl-6-oxo-, ethyl ester
• CAS NO: 78756-03-3
• Molecular Formula: C₁₅H₁₅N₃O₃
• Molecular Weight: 285.2979
• Mol File: 78756-03-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 527°C at 760 mmHg
• Flash Point: 272.5°C
• Density: 1.33g/cm³
• Vapor Pressure: 3.38E-11mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: ethyl 5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate(78756-03-3)
• EPA Substance Registry System: ethyl 5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate(78756-03-3)

Safety Data

• Hazardous Substances Data: 78756-03-3(Hazardous Substances Data)

Usage

General Description

Ethyl 5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate is a chemical compound with a complex molecular structure. It belongs to the class of benzodiazepine derivatives, which are commonly used as pharmaceuticals for their sedative, hypnotic, anxiolytic, and muscle relaxant properties. The presence of an ethyl group and a carboxylate functional group indicates that it is an ester derivative. The compound's specific chemical properties and potential uses would likely require further analysis and investigation.

Upstream product

• 1350523-27-1 (3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(4-methylphenyl)iodonium tosylate 
• 1350523-17-9 (3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(phenyl)iodonium tosylate 
• 1350523-19-1 (3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(2-thiophenyl)iodonium tosylate 
• 1350523-21-5 (3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(3-thiophenyl)iodonium tosylate 
• 1350523-23-7 (3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(4-methoxyphenyl)iodonium tosylate 
• 1350523-25-9 (3-(ethoxycarbonyl)-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepin-8-yl)(3-methoxyphenyl)iodonium tosylate 
• 200408-05-5 ethyl 5-methyl-6-oxo-8-tributylstannyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate 

Relevant articles and documents

Facile aromatic radiofluorination of [18F]flumazenil from diaryliodonium salts with evaluation of their stability and selectivity

Aromatic radiofluorination of the diaryliodonium tosylate precursor with [18F]fluoride ions has been applied successfully to access [ 18F]flumazenil in high radiochemical yields of 67.2 ± 2.7% (decay corrected). The stability and reactivity of the diaryliodonium tosylate precursor plays a key role in increasing the production of 18F- labelled molecules under the fluorine-18 labelling condition. Various conditions were explored for the preparation of [18F]flumazenil from different diaryliodonium tosylate precursors. Optimum incorporation of [ 18F]fluoride ions in the 4-methylphenyl-mazenil iodonium tosylate precursor (5f) was achieved at 150°C for 5 min by utilizing 4 mg of the precursor, K2.2.2/K2CO3 complex, and the radical scavenger in N,N-dimethylformamide. This approach was extended to a viable method for use in automated synthesis with a radiochemical yield of 63.5 ± 3.2% (decay corrected, n = 26) within 60.0 ± 1.1 min. [ 18F]Flumazenil was isolated by preparative HPLC after the reaction was conducted under improved conditions and exhibited sufficient specific activity of 370-450 GBq μmol-1, with a radiochemical purity of >99%, which will be suitable for human PET studies. The Royal Society of Chemistry 2011.