78756-37-3 Usage
Description
Ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate is a complex organic compound that belongs to the class of benzo[f]imidazo[1,5-a][1,4]diazepine derivatives. It is characterized by the presence of a bromo substituent at the 8th position, a methyl group at the 5th position, and a carboxylate group attached to the ethyl ester at the 3rd position. ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate exhibits a unique molecular structure that makes it a valuable entity in the field of medicinal chemistry and synthetic organic chemistry.
Uses
Used in Pharmaceutical Research:
Ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate is used as an Informer compound X2 of the Aryl Halide Chemistry Informer Library. This library, developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., comprises 18 drug-like molecules that are representative of those encountered in complex synthesis. ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate serves as a benchmark for chemists to screen new reactions, allowing them to directly compare and analyze the successes and shortcomings of different methods and research teams.
Used in Method Development:
ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate is also utilized to facilitate deeper method development for performance or utility in the pharmaceutical industry. By incorporating ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate into their research, chemists can enhance their understanding of reaction mechanisms, optimize synthetic routes, and improve the overall efficiency of drug discovery and development processes.
Check Digit Verification of cas no
The CAS Registry Mumber 78756-37-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,7,5 and 6 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78756-37:
(7*7)+(6*8)+(5*7)+(4*5)+(3*6)+(2*3)+(1*7)=183
183 % 10 = 3
So 78756-37-3 is a valid CAS Registry Number.
78756-37-3Relevant articles and documents
The synthesis and anti-inflammatory evaluation of 1,2,3-triazole linked isoflavone benzodiazepine hybrids
Menghere?, Gabriel,Olajide, Olumayokun,Hemming, Karl
supporting information, p. 306 - 321 (2021/02/05)
Copper catalyzed azide-alkyne cycloaddition was used for the first time to access a small series of eight novel 1,2,3-triazole linked isoflavone benzodiazepine hybrids. As part of this work, a previously unreported alkyne substituted pyrrolo[1,4]benzodiaz
Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications
Preshlock, Sean,Calderwood, Samuel,Verhoog, Stefan,Tredwell, Matthew,Huiban, Mickael,Hienzsch, Antje,Gruber, Stefan,Wilson, Thomas C.,Taylor, Nicholas J.,Cailly, Thomas,Schedler, Michael,Collier, Thomas Lee,Passchier, Jan,Smits, René,Mollitor, Jan,Hoepping, Alexander,Mueller, Marco,Genicot, Christophe,Mercier, Jo?l,Gouverneur, Véronique
supporting information, p. 8361 - 8364 (2016/07/07)
[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18
PREPARATION METHOD OF FLUMAZENIL LABELED WITH FLUORINE-18 USING DIARYL IODONIUM SALT PRECURSOR
-
Paragraph 0023; 0052, (2014/05/07)
Disclosed is the synthesis of [18F]flumazenil that is useful in imaging epileptic lesions by PET (positron emission tomography). A method for preparing [18F]flumazenil by reacting a diaryliodonium salt precursor with the positron-emi
