131666-45-0

Usage

Uses

Used in Pharmaceutical Industry:
4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 5,6-dihydro-8-hydroxy-5-methyl-6-oxo-, ethyl ester is used as an impurity in the synthesis of Flumazenil (F500450), a benzodiazepine antagonist. It plays a crucial role in preventing or abolishing the effects of benzodiazepines at the receptor level, making it valuable for the development of medications targeting benzodiazepine-related conditions.
Used in Research Applications:
4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylicacid, 5,6-dihydro-8-hydroxy-5-methyl-6-oxo-, ethyl ester may also be utilized in research settings to study the structure-activity relationships of imidazo-benzodiazepines and their potential therapeutic applications. Its unique structure could provide insights into the development of new drugs with improved efficacy and selectivity.

Upstream product

• 78756-37-3 ethyl 8-bromo-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate 
• 64-17-5 ethanol 
• 130477-45-1 7-methoxy-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5-(1H)-dione 
• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 37795-77-0 6-methoxy-2H-3,1-benzoxazine-2,4(1H)-dione 
• 2999-46-4 Ethyl isocyanoacetate 

Relevant academic research and scientific papers

Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate

The conversion of aryl halides to phenols under mild reaction conditions is a longstanding and formidable challenge in organic chemistry. Herein, we report the rational design of a broadly applicable Pd-catalyzed method to prepare phenols with benzaldehyde oxime as a hydroxide surrogate. These reactions occur under mildly basic conditions and enable the late-stage hydroxylation of several functionally-dense drug-like aryl halides.

Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction

Parallel synthesis and mass-directed purification of a modular ligand library, high-throughput experimentation, and rational ligand evolution have led to a novel copper catalyst for the synthesis of phenols with a traceless hydroxide surrogate. The mild reaction conditions reported here enable the late-stage synthesis of numerous complex, druglike phenols.

[18 F] - LABELLED ANALOGUES OF FLUMAZENIL AS IN VIVO IMAGING AGENTS

The present invention provides radiofluorinated compounds useful for in vivo imaging GABAA receptors. Also provided by the present invention is a method of synthesis for the radiofluorinated compounds of the invention, in particular an automate