787575-50-2

Upstream product

• 67-56-1 methanol 
• 1879-56-7 2-(2-bromophenoxy)acetic acid 
• 95-56-7 2-hydroxybromobenzene 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 35368-48-0 2-(2-Bromo-phenoxy)-thioacetamide 
• 787576-48-1 (2-bromo-phenoxy)-acetaldehyde methyl hemiacetal 
• 68959-99-9 2-((2-bromophenoxy)methyl)-4,5-dihydro-1H-imidazole 
• 1332878-87-1 methyl 2-(2-bromophenoxy)-3-oxopropanoate 

Relevant academic research and scientific papers

BIARYL PIPERIDINE AMIDE COMPOUNDS AND METHODS OF USE THEREOF

The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.

Exploring multitarget interactions to reduce opiate withdrawal syndrome and psychiatric comorbidity

Opioid addiction is often characterized as a chronic relapsing condition due to the severe somatic and behavioral signs, associated with depressive disorders, triggered by opiate withdrawal. Since prolonged abstinence remains a major challenge, our intere

ISOQUINOLINE-5-SULFONIC ACID AMIDES AS INHIBITORS OF AKT (PROTEIN KINASE B)

The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.

Fused piperidine substituted arylsulfonamides as beta 3-agonists

Fused piperidine substituted arylsulfonamides are beta 3 adrenergic receptor agonists with very little beta 1 and beta 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.

Applicability of Hammett Equation to Kinetics of Acid-catalysed Esterification of ortho-Substituted Phenoxyacetic, Phenylmercaptoacetic and Phenylsulphonylacetic Acids by Methanol

Correlation analysis of the title rate data shows that the steric effects of ortho-substituents are absent at the reaction centre.