787615-01-4

Basic information

• Product Name: ISOQUINOLINE-8-CARBALDEHYDE
• Synonyms: 8-Carboxyisoquinoline;8-Formylisoquinoline, 8-Formyl-2-azanaphthalene;RARECHEM AM LA 0004;ISOQUINOLINE-8-CARBALDEHYDE;ISOQUINOLINE-8-CARBOXALDEHYDE;8-Isoquinolinecarboxaldehyde;8-Formylisoquinoline
• CAS NO: 787615-01-4
• Molecular Formula: C₁₀H₇NO
• Molecular Weight: 157.17
• EINECS: 604-604-1
• Product Categories: Building Blocks;Isoquinoline
• Mol File: 787615-01-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: /
• Density: 1.223g/cm3
• Vapor Pressure: 0.000153mmHg at 25°C
• Refractive Index: 1.687
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.49±0.23(Predicted)
• CAS DataBase Reference: ISOQUINOLINE-8-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOQUINOLINE-8-CARBALDEHYDE(787615-01-4)
• EPA Substance Registry System: ISOQUINOLINE-8-CARBALDEHYDE(787615-01-4)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 787615-01-4(Hazardous Substances Data)

Usage

General Description

ISOQUINOLINE-8-CARBALDEHYDE, also known as 8-Isoquinolinecarboxaldehyde, is a chemical compound that is commonly used as a chemical building block in the pharmaceutical and organic synthesis industries. It is a yellow to brownish liquid with a strong, pungent odor and is widely used as a flavoring and fragrance agent. It is also used as a key intermediate in the production of pharmaceuticals and agrochemicals. ISOQUINOLINE-8-CARBALDEHYDE is known for its ability to form stable complexes with transition metals, making it useful in various catalytic and synthesis reactions. Additionally, it has been investigated for its potential antimicrobial and insecticidal properties, making it a versatile and valuable chemical compound in various industries.

InChI:InChI=1/C10H7NO/c12-7-9-3-1-2-8-4-5-11-6-10(8)9/h1-7H

Upstream product

• 63927-22-0 8-bromo-isoquinoline 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102

Although the selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor UCPH-101 has become a standard pharmacological tool compound for in vitro and ex vivo studies in the EAAT research field, its inability to penetrate the blood-brain barrier makes it unsuitable for in vivo studies. In the present study, per os (p.o.) administration (40 mg kg-1) of the closely related analogue UCPH-102 in rats yielded respective plasma and brain concentrations of 10.5 and 6.67 μm after 1 h. Three analogue series were designed and synthesized to improve the bioavailability profile of UCPH-102, but none displayed substantially improved properties in this respect. In vitro profiling of UCPH-102 (10 μm) at 51 central nervous system targets in radioligand binding assays strongly suggests that the compound is completely selective for EAAT1. Finally, in a rodent locomotor model, p.o. administration of UCPH-102 (20 mg kg-1) did not induce acute effects or any visible changes in behavior. EAAT1 inhibition beyond the BBB: In the present study, oral administration (40 mg kg-1) of the selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor UCPH-102 in rats yielded respective plasma and brain concentrations of 10.5 and 6.67 μm after 1 h. In vitro profiling of UCPH-102 (10 μm) at 51 central nervous system targets in radioligand binding assays strongly suggests that the compound is fully selective for EAAT1.