787615-46-7

Upstream product

• 80-48-8 methyl p-toluene sulfonate 
• 155075-23-3 (2R,4R)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 79433-95-7 (2R,4S)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 

Downstream Products

• 787615-52-5 N-1-(benzyloxycarbonyl)-(4R)-(tert-butyloxycarbonylamino)-(2R)-(thymin-1-ylmethyl)pyrrolidine 
• 787615-50-3 N-1-(benzyloxycarbonyl)-(4R)-(tert-butyloxycarbonylamino)-(2R)-(O-mesylmethyl)pyrrolidine 
• 787615-48-9 (2R,4R)-N-1-(benzyloxycarbonyl)-4-(tert-butyloxycarbonylamino)proline methyl ester 
• 787615-58-1 (2R,4R)-N-1-(benzyloxycarbonyl)-4-(tert-butyloxycarbonylamino)pyrrolidin-2-methanol 
• 787615-47-8 (2R,4R)-N-1-(benzyloxycarbonyl)-4-azidoproline methyl ester 

Relevant academic research and scientific papers

AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE

The invention relates to azabenzofuranyl compounds of Formula (I) with anti-cancer and/or anti-inflammatory activity and more specifically to azabenzofuranyl compounds which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses

Compounds having activity against production of an inflammatory cytokine of formula (I)′: 1A′ is pyrrole; R1′ is phenyl or naphthyl; R2′ is pyridyl or pyrimidinyl; R3′ is (IIa)′, (IIb)′ or (IIc)′: 2m′ is 1; E′ is nitrogen; D′ is >C(R5′)—, R5′ is hydrogen, Substituent α′ or Substituent β′; B′ is nitrogen-containing 5-membered heterocyclic; R4′ is 1 to 3 substituents from Substituent α′, Substituent β′ and Substituent γ′; R1′ and R3′ are bonded to two atoms of the pyrrole adjacent to the pyrrole atom bonded to R2′; Substituent α′ is hydroxyl, nitro, cyano, halogen, alkoxy, halogeno alkoxy, alkylthio, halogeno alkylthio or —NRa′Rb′; Ra′ and Rb′ are hydrogen, alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl, or Ra′ and Rb′ with the nitrogen atom form a heterocyclyl; Substituent β′ is alkyl, alkenyl, alkynyl, aralkyl or cycloalkyl; Substituent γ′ is oxo, hydroxyimino, alkoxyimino, alkylene, alkylenedioxy, alkylsulfinyl, alkylsulfonyl, aryl, aryloxy, alkylidenyl or aralkylidenyl.

Chimeric (aeg-pyrrolidine)PNAs: Synthesis and stereo-discriminative duplex binding with DNA/RNA

The design and facile conversion of naturally occurring 4-hydroxyproline to all four diastereomers of thymine pyrrolidine PNA monomer, (2R,4S)-adenine, -guanine and -cytosine monomers and their incorporation into duplex forming PNA oligomers is reported,