79433-95-7

Basic information

• Product Name: N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER
• Synonyms: N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER;(2R,4S)-1-benzyl 2-Methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;(2R,4S)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 2-methyl 1-(phenylmethyl) ester;N-Carbobenzoxy-trans-4-Hydroxy-D-proline methyl ester
• CAS NO: 79433-95-7
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.29
• Mol File: 79433-95-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 422.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.313±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.25±0.40(Predicted)
• CAS DataBase Reference: N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER(79433-95-7)
• EPA Substance Registry System: N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER(79433-95-7)

Safety Data

• Hazardous Substances Data: 79433-95-7(Hazardous Substances Data)

Usage

General Description

N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER, also known as N-Cbz-4-hydroxy-D-proline methyl ester, is a chemical compound used in the synthesis of pharmaceuticals and organic molecules. It consists of a 4-hydroxy-D-proline molecule with a methyl ester group and a carbobenzyloxy (Cbz) protecting group. N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER is commonly used as an intermediate in the production of peptide-based pharmaceuticals and is also utilized in research and development of new drugs and organic compounds. N-CBZ-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER is a versatile chemical with various applications in medicinal and organic chemistry.

InChI:InChI:1S/C14H17NO5/c1-19-13(17)12-7-11(16)8-15(12)14(18)20-9-10-5-3-2-4-6-10/h2-6,11-12,16H,7-9H2,1H3

Upstream product

• 501-53-1 benzyl chloroformate 
• 51-35-4 4R-4-hydroxyproline 
• 130930-25-5 (R,R)-4-hydroxy-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid 
• 3398-22-9 trans-4-hydroxyproline 
• 155075-23-3 (2R,4R)-1-benzyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 67-56-1 methanol 
• 155153-78-9 (4S)-1-[(benzyloxy)carbonyl]-4-hydroxy-D-proline 
• 186581-53-3 diazomethane 
• 618-28-0 trans-4-hydroxy-D,L-proline 

Downstream Products

• 1269622-56-1 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 1269622-57-2 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-58-3 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-formyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-59-4 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-[hydroxy-(1,3,5-trimethyl-1H-pyrazol-4-yl)-methyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-60-7 (2S,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-61-8 (2S,4S)-4-hydroxy-2-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-64-1 (2R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-2-[phenoxythiocarbonyloxy-(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 1269622-71-0 (2S,4R)-4-fluoro-2-(1,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 268729-12-0 4S-O⁴(t-butyl)-N₁-(fluorenylmethyloxycarbonyl)-D-proline 
• 79775-07-8 4S-O⁴(t-butyl)-D-Pro acid 
• 787615-46-7 (2R,4S)-N-1-(benzyloxycarbonyl)-4-(p-toluenesulfonyloxy)proline methyl ester 
• 340981-85-3 benzoic acid 2-({2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 340981-86-4 2-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-N-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-acetamide 
• 340981-83-1 [(2R,4R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetic acid ethyl ester 

Relevant articles and documents

ANTIBODY-DRUG CONJUGATES COMPRISING ANTI-B7-H3 ANTIBODIES

The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-B7-H3 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind B7-H3, as well as methods of making and using these anti-B7-H3 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications

DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE

Provided herein are a dihydropyrimidine compound and use as a medicament, especially application as a medicament used for treating and preventing hepatitis B. Specifically, provided herein is a compound having Formula (I) or (Ia), or a stereisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicament, especially use as a medicament for treating and preventing hepatitis B.

HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES

The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein