787622-23-5Relevant academic research and scientific papers
Inhibitory effects of 6-alkoxycoumarin and 7-alkoxycoumarin derivatives on lipopolysaccharide/interferon γ-stimulated nitric oxide production in RAW264 cells
Adfa, Morina,Itoh, Tomohiro,Hattori, Yosuke,Koketsu, Mamoru
experimental part, p. 963 - 966 (2012/09/21)
Coumarin and its derivatives are well known for their anti-inflammatory and anti-oxidative effects. In this study, we synthesized 32 coumarin derivatives from commercially available 6-hydroxycoumarin (6HC) and 7-hydroxycoumarin (7HC) and examined their ef
A new gold-catalyzed domino cyclization and oxidative coupling reaction
Wegner, Hermann A.,Ahles, Sebastian,Neuburger, Markus
supporting information; experimental part, p. 11310 - 11313 (2009/10/17)
Gold-catalyzed domino cyclization and oxidative coupling reaction for synthesis of dicoumarins was studied. Gold was thought to be an unreactive metal before its catalyzed reaction was discovered. HAuCl4 was suspended in dry 1,2-dichloroethane (DCE), whereas protic solvent gave only monomer and UV absorption and fluorescence properties of dicoumarins were similar to those of monomers. The crude product was purified by flash column chromatography on silica and gold catalyst performed two different functions. Dicoumarins, scaffolds of natural products has interesting biological properties whereas, potential photostable UV-absorbent materials were accessed in two steps from commercially available starting materials. The reaction generally proceeded in moderate-to-good yields, tolerating a variety of substituents on the aromatic moiety.
Heterocyclic mchr1 antagoists
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Page/Page column 46-47, (2010/11/24)
This invention relates to novel heterocycles which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), also referred to as 11 CBy, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in
SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS
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Page 82-83, (2008/06/13)
This invention relates to novel heterocycles which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), also referred to as 11CBy, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in medicines. Compounds of the invention have the formula: (I)
