787629-25-8Relevant academic research and scientific papers
Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels
Aksimentiev, Aleksei,Chen, Feng,Joshi, Himanshu,Roy, Arundhati,Shen, Jie,Ye, Ruijuan,Zeng, Huaqiang
, p. 4806 - 4813 (2020)
Reported herein is a series of pore-containing polymeric nanotubes based on a hydrogen-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 ? diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC50=0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides (EC50=0.47 μm). Notably, even in cholesterol-rich environment, iodide transport activity remains high with an EC50 of 0.37 μm. Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior-pointing methyl groups.
Oxidative coupling polymerization of bishydrazide for the synthesis of poly(diacylhydrazine): Oxidative preparation of oxidatively degradable polymer
Nagashima, Kentaro,Kihara, Nobuhiro,Iino, Yusuke
, p. 4230 - 4238 (2012/11/13)
The oxidative coupling polymerization of bishydrazide is successfully performed to form poly(diacylhydrazine) (PDAH), which is an oxidatively degradable polymer. Oxone is an effective oxidant, and a mixture of an aprotic polar solvent, water, and acetonitrile or N,N-dimethylacetamide is necessary as the solvent. On treatment of PDAH with sodium hypochlorite solution or hydrogen peroxide, the PDAH is rapidly oxidized and degraded to the corresponding dicarboxylic acid. When hydrogen peroxide is used as the oxidant, the addition of acetonitrile and potassium carbonate is necessary for effective degradation. PDAH exhibits high thermal stability in air and a high Tg value. No oxidation is observed in air. Thus, PDAH is an oxidatively degradable high-performance polymer that is stable toward oxygen.
Helical molecular duplex strands: Multiple hydrogen-bond-mediated assembly of self-complementary oligomeric hydrazide derivatives
Yang, Yong,Yang, Zhi-Yong,Yi, Yuan-Ping,Xiang, Jun-Feng,Chen, Chuan-Feng,Wan, Li-Jun,Shuai, Zhi-Gang
, p. 4936 - 4946 (2008/02/09)
(Chemical Equation Presented) Careful examination of the X-ray structure of a ditopic hydrazide derivative 7 led to the concept that with malonyl groups as interhydrazide linkers hydrogen-bonding-mediated molecular duplex strands might be obtained. Comple
Hydrogen bonded oligohydrazide foldamers and their recognition for saccharides
Hou, Jun-Li,Shao, Xue-Bin,Chen, Guang-Ju,Zhou, Yan-Xia,Jiang, Xi-Kui,Li, Zhan-Ting
, p. 12386 - 12394 (2007/10/03)
This paper describes the synthesis and characterization of the first series of hydrogen bonding-driven hydrazide foldamers and their recognition for alkyl saccharides in chloroform. Oligomers 1, 2-4, 5, 6, and 7, which contain one, two, four, six, or twel
