52959-28-1Relevant articles and documents
Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels
Aksimentiev, Aleksei,Chen, Feng,Joshi, Himanshu,Roy, Arundhati,Shen, Jie,Ye, Ruijuan,Zeng, Huaqiang
, p. 4806 - 4813 (2020/02/11)
Reported herein is a series of pore-containing polymeric nanotubes based on a hydrogen-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 ? diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC50=0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides (EC50=0.47 μm). Notably, even in cholesterol-rich environment, iodide transport activity remains high with an EC50 of 0.37 μm. Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior-pointing methyl groups.
CAVITY-CONTAINING OLIGOMERS AND POLYMERS EFFECTIVE IN CRYOPRESERVATION
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Paragraph 0035; 0129, (2019/06/09)
The present invention provides compositions and methods for cryopreservation utilizing aromatic cavity-containing oligomers and polymers that contain structural motifs capable of shape-inducing intramolecular bonding to form cavities. The cavity-containin
Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen-Bonding Junctions
Montarnal, Damien,Delbosc, Nicolas,Chamignon, Cécile,Virolleaud, Marie-Alice,Luo, Yingdong,Hawker, Craig J.,Drockenmuller, Eric,Bernard, Julien
, p. 11117 - 11121 (2016/07/06)
We designed efficient precursors that combine complementary associative groups with exceptional binding affinities and thiocarbonylthio moieties enabling precise RAFT polymerization. Well defined PS and PMMA supramolecular polymers with molecular weights up to 30 kg mol?1are synthesized and shown to form highly stable supramolecular diblock copolymers (BCPs) when mixed, in non-polar solvents or in the bulk. Hierarchical self-assembly of such supramolecular BCPs by thermal annealing affords morphologies with excellent lateral order, comparable to features expected from covalent diblock copolymer analogues. Simple washing of the resulting materials with protic solvents disrupts the supramolecular association and selectively dissolves one polymer, affording a straightforward process for preparing well-ordered nanoporous materials without resorting to crosslinking or invasive chemical degradations.