787631-82-7Relevant academic research and scientific papers
K2S2O8-promoted [2+2]-cycloaddition of benzyl-2-(3-hydroxypropynyl)-benzoates: A new route to polysubstituted cyclobutanes
Zhu, Hai-Tao,Tong, Xiao-Juan,Zhou, Ni-Ni,Yang, De-Suo,Fan, Ming-Jin
supporting information, p. 5497 - 5500 (2016/11/19)
An efficient and convenient metal-free [2+2]-cycloaddition of benzyl-2-(3-hydroxypropynyl)-benzoates via allene processes has been developed, which provides impressive access to fused cyclobutanes from easily accessed π-components. This transformation involved the cleavage of two C–O bonds, the formations of two C–O bonds and two C–C bonds and showed some advantages, including mild conditions and wide substrate scope.
Facile synthesis of 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′- ones via iodine-promoted cascade cyclization
Zhu, Hai-Tao,Dong, Xue,Wang, Li-Jing,Zhong, Mei-Jin,Liu, Xue-Yuan,Liang, Yong-Min
supporting information, p. 10748 - 10750,3 (2020/09/02)
A novel and efficient synthetic approach to substituted 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′-ones has been developed via an iodine-promoted cascade cyclization of 2-(3-hydroxy-3,3-diarylprop-1-yn- 1-yl)benzoates. This sequential cascade process is concisely conducted at room temperature. Subsequent palladium-catalyzed Sonogashira, Suzuki, and Heck reactions of the resulting iodides proceed smoothly in good yields.
Bicyclic heterocycles useful as serine protease inhibitors
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Page/Page column 28, (2010/02/14)
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4, X
Biarylmethyl indolines, indoles and tetrahydroquinolines, useful as serine protease inhibitors
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Page 33, (2010/02/09)
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or hydrate form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4 an
