787633-82-3

Basic information

• Product Name: (R,S)-1-(4-chloro-2-nitrophenyl)ethylamine
• Synonyms: (R,S)-1-(4-chloro-2-nitrophenyl)ethylamine
• CAS NO: 787633-82-3
• Molecular Weight: 200.625
• Mol File: 787633-82-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R,S)-1-(4-chloro-2-nitrophenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-1-(4-chloro-2-nitrophenyl)ethylamine(787633-82-3)
• EPA Substance Registry System: (R,S)-1-(4-chloro-2-nitrophenyl)ethylamine(787633-82-3)

Safety Data

• Hazardous Substances Data: 787633-82-3(Hazardous Substances Data)

Upstream product

• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 787633-79-8 (R,S)-1-(4-chloro-2-nitrophenyl)ethanol 
• 787633-81-2 (R,S)-N-[1-(4-chloro-2-nitrophenyl)ethyl]phthalimide 

Relevant articles and documents

Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity

The disruption of the p53-Hdm2 protein-protein interaction induces cell growth arrest and apoptosis. We have identified the 1,4-benzodiazepine-2,5-dione scaffold as a suitable template for inhibiting this interaction by binding to the Hdm2 protein. Several compounds have been made with improved potency, solubility, and cell-based activities.

Substituted 1,4-diazepines and uses thereof

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are defined herein; X is a bivalent radical of: an alkane, a cycloalkane, an optionally-substituted arene, an optionally-substituted heteroarene, an optionally-substituted arylalkane or an optionally-substituted heteroarylalkane; and R3 is —CO2Rd, —CO2M, —OH, —NHRd, —SO2Rd, —NHCONHRd, optionally-substituted amidino or optionally-substituted guanidino; or R3—X— is hydrogen or an electron pair; R4 is oxygen or —NR9R10; R5 is cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, aralkyl, heteroarylalkyl, or a saturated or partially unsaturated heterocycle, each of which is optionally substituted; and R6, R7 and R8 are independently hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, a saturated or partially unsaturated heterocycle, cycloalkylalkyl, aralkyl or heteroarylalkyl, each of which is optionally substituted; or R6 and R7, together with the carbon atom to which they are attached form a 3- to 7-membered carbocyclic ring optionally substituted 1 to 3 times with Ra.