78765-61-4

Upstream product

• 65095-24-1 3-furfurylidene-5-phenyl-3H-furan-2-one 
• 71-43-2 benzene 
• 98-01-1 furfural 
• 2051-95-8 succinylbenzene 

Downstream Products

• 1350839-77-8 2-[3-(4-ethylpiperazin-1-yl)propyl]-4-furan-2-ylmethyl-6-phenyl-2H-pyridazin-3-one 
• 1350839-81-4 4-furan-2ylmethyl-2-(3-morpholin-4-ylpropyl)-6-phenyl-2H-pyridazin-3-one 
• 1350839-85-8 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-4-furan-2ylmethyl-6-phenyl-2H-pyridazin-3-one 
• 1350839-70-1 2-[3-(4-benzylpiperazin-1-yl)propyl]-4-furan-2-ylmethyl-6-phenyl-2H-pyridazin-3-one 
• 1427044-95-8 C₂₃H₁₄N₂O₄ 
• 1427044-81-2 C₂₃H₁₇N₃O₄ 
• 1427044-89-0 C₂₃H₁₅N₃O₃ 
• 1402083-54-8 2-(3-(1-(furan-2-yl)-4-oxo-4-phenylbut-1-en-2-yl)ureido)acetic acid 
• 1402083-56-0 2-((4-furan-2-ylmethylene)-2-oxo-6-phenyl-3,4-dihydropyrimidin-1(2H)-yl)acetic acid 
• 78765-65-8 5-furylmethyl-6-phenyl-3(2H)-pyridazinone 

Relevant academic research and scientific papers

Ring Transformation of a 2(3H)-furanone Derivative into Oxazinone and Pyrimidinone Heterocycles

The conversion of the 2(3H)-furanone into the oxazinone and pyrimidinone derivatives is studied. A 2-(furan-2-ylmethylene)-4-oxo-4-phenylbutanoyl azide 3 was synthesized to carry out these conversions through its thermolysis in dry benzene and/or base-cat

Novel synthesis of some isatin hydrazones and pyridazinophthalazines

The acid hydrazides bearing furyl, pyrazolyl, and indolyl rings 2 condense with isatin to give the corresponding hydrazones 3. Ring closure of the latter in an HCl=AcOH mixture led to the construction of a new pyrrolinone ring 4. The hydrazides 2 condensed also with phthalic anhydride to give the corresponding pyridazinophthalazines 5.

Conversion of some 2(3H)-furanones into pyrrolinotriazine and oxazolopyrimidine derivatives

2(3H)-Furanones 1 were utilized for the construction of pyrrolinotriazine and oxazolopyrimidine derivatives 4 and 9. Thus, 1 reacted with glycine in ethanol at 70°C to give the acids 2, which were cyclized into the pyrrolin-5-one derivatives 3 by the acti

Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substitutedpiperazine-1-yl) propyl]pyridazin-3(2H)-one derivatives as anticancer agents

A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4- substituted piperazine-1-yl)propyl] pyridazin- 3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.