78765-65-8

Upstream product

• 71-43-2 benzene 
• 98-01-1 furfural 
• 2051-95-8 succinylbenzene 
• 65095-24-1 3-furfurylidene-5-phenyl-3H-furan-2-one 
• 74143-82-1 (E)-enol lactone of β-benzoyl-α-(2-furfurylidene)propionic acid 
• 323579-66-4 2-[1-Furan-2-yl-meth-(E)-ylidene]-4-oxo-4-phenyl-butyric acid hydrazide 
• 78765-61-4 2-[1-Furan-2-yl-meth-(E)-ylidene]-4-oxo-4-phenyl-butyric acid hydrazide 

Downstream Products

• 1350839-70-1 2-[3-(4-benzylpiperazin-1-yl)propyl]-4-furan-2-ylmethyl-6-phenyl-2H-pyridazin-3-one 
• 1350839-77-8 2-[3-(4-ethylpiperazin-1-yl)propyl]-4-furan-2-ylmethyl-6-phenyl-2H-pyridazin-3-one 
• 1350839-81-4 4-furan-2ylmethyl-2-(3-morpholin-4-ylpropyl)-6-phenyl-2H-pyridazin-3-one 
• 1350839-85-8 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-4-furan-2ylmethyl-6-phenyl-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substitutedpiperazine-1-yl) propyl]pyridazin-3(2H)-one derivatives as anticancer agents

A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4- substituted piperazine-1-yl)propyl] pyridazin- 3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.

A facile method for the synthesis of 6-aryl-1-(3-chloropropanoyl)-4-[(E)-1- (2-furyl)methylidene)]-1,2,3,4-tetrahydr o-3-pyridazinones and 2-(2-chloroethyl)-5-[α-aracyl-β-(2-furyl)]-(E )-vinyl-1,3, 4-oxadiazoles

The 6-aryl-1-(3-chloropropanoyl)-4-[(E)-1-(2-furyl)methylidene)]-1,2,3,4- tetra-hydro-3-pyridazinones (6a-d) were synthesized by the reaction of acid chloride 3 with α-aracyl(β-2-furyl)acrylic acid hydrazides (2a-d) in a high yield, one pot reaction. On the other hand, 2-(2-chloroethyl)-5-[α- aracyl-β-(2-furyl)]-(E)-vinyl-1,3,4-oxadiazoles (7a-d) were also prepared by cyclodehydration of N1[α-aracyl-β-(2-furyl)acroyl- N2[3-chloro-propanoyl] hydrazine derivatives (4a-d). The proposed structures of the products were confirmed by elemental analysis, spectral data and chemical evidence.