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Usage

Uses

Used in Pharmaceutical Industry:
(S)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID is used as an anti-inflammatory and analgesic agent for the treatment of conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is effective in reducing inflammation and pain due to its ability to inhibit prostaglandin production, thereby providing relief to patients suffering from these conditions.
Used in Pain Management:
(S)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID is used as a pain reliever for various types of pain, including acute and chronic pain. Its anti-inflammatory properties make it suitable for managing pain associated with inflammation, while its analgesic effects help in alleviating other types of pain.
It is crucial to follow the guidance of a healthcare professional when using (S)-ACETYLAMINO-CYCLOHEXYL-ACETIC ACID to ensure its safe and effective use. Patients should be aware of potential side effects and the possibility of interactions with other medications to maximize the benefits and minimize risks associated with its use.

Upstream product

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• 108-24-7 acetic anhydride 
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• 78761-29-2 (S)-Acetylamino-(S)-cyclohex-2-enyl-acetic acid 2-acetylamino-2-phenyl-ethyl ester 
• 78761-29-2 (S)-Acetylamino-(R)-cyclohex-2-enyl-acetic acid 2-acetylamino-2-phenyl-ethyl ester 
• 56613-80-0 D-(-)-2-amino-2-phenyl-1-ethanol 
• 78761-26-9 N-[(1R)-2-hydroxy-1-phenylethyl]acetamide 
• 326894-40-0 (S)-(-)-N-[cyclohexyl(phenyl)methyl]-N-(4-methoxyphenyl)amine 
• 169698-50-4 (E)-N-(cyclohexylmethylene)-4-methoxyphenylamine 
• 32908-43-3 (-)-(S)-N-(cyclohexylphenylmethyl)acetamide 

Relevant academic research and scientific papers

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

CYSTEINE PROTEASE INHIBITORS

Compounds of the formula (I) wherein R1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; or R1a and R1b together define a saturated cyclic amine with 3-6 ring atoms; R2a and Rs

Impact on hydrogenation catalytic cycle of the R groups Cyclic feature in "r-SMS-Phos"

A series of R-SMS-Phos ligands was evaluated in the Rh(I)-catalyzed hydrogenation of a set of olefins showing a marked influence of the cyclic nature and structure of the R groups. Overall, cPen- and Cy-SMS-Phos performed efficiently, while Ph- and Bn-SMS-Phos exhibited slower kinetics and furnished lower ees also compared with C6F5CH2-SMS-Phos. The Rh(I)-(Cy-SMS-Phos) catalyst was screened under mild conditions displaying excellent enantioselectivities and high TOFs. Cases of catalysis under catalyst or substrate control were identified.

Facile asymmetric synthesis of α-amino acids employing chiral ligand-mediated asymmetric addition reactions of phenyllithium with imines

A three-step methodology involving an external chiral ligand-mediated asymmetric addition of phenyllithium to an anisidine imine, oxidative removal of N-PMP group, and finally oxidative conversion of the phenyl group to a carboxyl group provides a facile synthesis of optically pure α-amino acid derivatives beating a bulky α-substituent. (C) 2000 Elsevier Science Ltd.

Efficient chemoenzymatic synthesis of enantiomerically pure α-amino acids

A general two-step chemoenzymatic synthesis for enantiomerically pure natural and nonnatural α-amino acids is presented. In the first step of the sequence, the ubiquitous educts aldehyde, amide and carbon monoxide react by palladium-catalyzed amidocarbonylation to afford the racemic N-acyl amino acids in excellent yields. In the second step, enzymatic enantioselective hydrolysis yields the free optically pure a-amino acid and the other enantiomer as the N-acyl derivative, both in optical purities of 85-99.5% ee. The advantage of the chemoenzymatic process compared to other amino acid synthesis are demonstrated by the preparation of various functionalized (-OR, -Cl, -F, -SR) α-amino acids on a 10-g scale.

On Amino Acid Antagonists,IV.-Separation and Determination of the Configurations of the Stereoisomeric N-Acetyl-2-(2'-cyclohexenyl)glycines

The D-(+)-(1-phenylethyl)amides 5 as well as the D-(-)-O-acetyl-α-phenylglycinolamides 7 of the title compounds were separated on silica gel into the four diastereomeric compounds.All attempts failed to hydrolyze 5 and 7 to the corresponding acids.In contrast the diastereomeric D-(-)-N-acetyl-α-phenylglycinol esters 10 which were separated on silica gel were hydrolysed to the optically active acids 3a-d.The absolute configurations at C-2 in 3 were determined by correlation with the saturated glycine derivatives of known stereochemistry.The relative configurationsand hence the absolute configurations at C-1' in 3a-d were deduced from the NMR- and CD-spectra and were confirmed by X-ray analysis of 3a.Only the amino acid 3b with the (2S,1'R)-configuration exhibits biological activity.