Calcitriol-d6, also known as 1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6, is a synthetically produced internal standard used for the quantification of calcitriol by gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS). It is a derivative of calcitriol, which is synthesized from 7-dehydro cholesterol in humans through a non-enzymatic photochemical reaction with UV light. Calcitriol plays a crucial role in increasing calcium absorption in the intestine and promoting bone mineralization by stimulating osteoblasts.
78782-99-7
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Basic information
- Product Name: Calcitriol-d6
- Synonyms: (1a,3,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol-d6;1a,25-Dihydroxycholecalciferol-d6;1a,25-Dihydroxyvitamin D3-d6;Calcijex-d6;Calcitriol-d6;Ro 21-5535-d6;Rocaltrol-d6;Silkis-d6
- CAS NO:78782-99-7
- Molecular Formula: C27H44O3
- Molecular Weight: 423
- EINECS: N/A
- Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Isotope Labelled Compounds
- Mol File: 78782-99-7.mol
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Chemical Properties
- Melting Point: 77-79°C
- Boiling Point: N/A
- Flash Point: 14℃
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
- Solubility: N/A
- Stability: Light and temperature sensitive
- CAS DataBase Reference: Calcitriol-d6(CAS DataBase Reference)
- NIST Chemistry Reference: Calcitriol-d6(78782-99-7)
- EPA Substance Registry System: Calcitriol-d6(78782-99-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- RIDADR: UN1170 - class 3 - PG 2 - Ethanol, solution
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 78782-99-7(Hazardous Substances Data)
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78782-99-7 Usage
Uses
Used in Pharmaceutical and Biomedical Research:Calcitriol-d6 is used as an analytical standard for the quantitative analysis of calcitriol concentration in human serum via LC-MS. This application is essential for monitoring and managing various health conditions related to vitamin D deficiency or excess, such as rickets, osteoporosis, and certain cancers.
Used in Quality Control and Method Development:
Calcitriol-d6 serves as a valuable tool in the development and validation of analytical methods for the accurate measurement of calcitriol levels in biological samples. It helps ensure the reliability and reproducibility of test results, which is crucial for research and clinical applications.
Used in Toxicology and Forensic Analysis:
In toxicology and forensic analysis, Calcitriol-d6 can be employed as a reference material to determine the presence and concentration of calcitriol in samples, such as blood or tissue, to aid in the investigation of potential vitamin D-related toxicity or other health issues.
Used in Nutritional Assessment:
Calcitriol-d6 can be utilized in nutritional assessment studies to evaluate the effects of dietary interventions or supplements on calcitriol levels and their impact on bone health and overall well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 78782-99-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,7,8 and 2 respectively; the second part has 2 digits, 9 and 9 respectively.Calculate Digit Verification of CAS Registry Number 78782-99:
(7*7)+(6*8)+(5*7)+(4*8)+(3*2)+(2*9)+(1*9)=197
197 % 10 = 7
So 78782-99-7 is a valid CAS Registry Number.
78782-99-7Upstream product
78782-99-7Downstream Products
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Calcitriol-d6
