78782-98-6

Usage

Uses

Used in Mass Spectrometry Applications:
Calcifediol-d6 is used as an internal standard for the quantification of Vitamin D3 by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry. Its stable isotope labeling allows for accurate measurement and quantification of Vitamin D3 levels in various samples, ensuring reliable results in research and clinical settings.
Used in Clinical Diagnostics:
In the clinical diagnostics industry, Calcifediol-d6 is used as an internal standard for the quantitation of 25-hydroxyvitamin D2/D3 in human serum by liquid chromatography tandem mass spectrometry. This application aids in the assessment of Vitamin D status, which is crucial for monitoring and managing various health conditions related to Vitamin D deficiency or excess.

Upstream product

• 170081-45-5 3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(E),7(E),10(19)-triene 
• 41251-37-0 methyl-d3-magnesium iodide 
• 135359-41-0 de-A,B-24-(methoxycarbonyl)-cholestan-8-one 
• 135359-40-9 de-A,B-24-(methoxycarbonyl)-cholestan-8β-ol 
• 100858-27-3 (S)-(Z)-{2-[5-(tert-butyldimethylsiloxy)-2-methylenecyclohexylidene]ethyl}diphenylphosphine oxide 
• 116535-65-0 (1R,3aR,4S,7aR)-octahydro-1-[(S)-1-iodopropan-2-yl]-7a-methyl-1H-inden-4-ol 
• 155498-04-7 <<1-(3-butenyl)>-3-butynyloxy>(1,1-dimethylethyl)dimethylsilane 
• 135359-42-1 (R)-methyl 5-((1R,3aS,7aR,E)-4-((Z)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)hexanoate 

Downstream Products

• 78782-99-7 C₂₇H₃₈⁽²⁾H₆O₃ 

Relevant academic research and scientific papers

Determination of 25-hydroxyvitamin D in human plasma using high-performance liquid chromatography-tandem mass spectrometry

We report here the development of a precise and sensitive method to determine 25-hydroxyvitamin D (25-OH-D2/ -D3) in human plasma using high-perfomance liquid chromatography-tandem mass-mass spectrometry with atomospheric pressure ch

Preparation method of 25-hydroxyvitamin D3, 1alpha, 25-dihydroxyvitamin D3 and isotope internal standard compound thereof

The invention discloses a preparation method of 25-hydroxyvitamin D3 and 1alpha, 25-dihydroxyvitamin D3 and an isotope internal standard compound thereof. The preparation method comprises the following steps: a compound III is subjected to SO2 conjugate protection, O3 oxidation, NaBH4 reduction, iodination ring opening, conjugate addition with acrylate, and reaction with a methyl Grignard reagentor isotope labeled methyl Grignard reagent, a silicon protecting group is removed under the action of TBAF, and a product is obtained through ultraviolet irradiation configuration inversion under thecatalysis of 9-acetyl anthracene. The method is good in reaction selectivity, high in total yield, simple and convenient to operate and short in isotope introduction step, and the isotope utilizationrate is greatly increased.

Synthesis of 25-hydroxyvitamin D3 and 26,26,26,27,27,27- hexadeutero-25-hydroxyvitamin D3 on solid support

(Chemical Equation Presented) A convenient five-step route to 25-hydroxylated vitamin D3 compounds on (hydroxymethyl)polystyrene support is reported. A CD-side chain fragment was anchored to the solid phase through an ester group at C25 and coupled to an

A short, flexible route to vitamin D metabolites and their side chain analogues

A short, flexible approach to 25-functionalized vitamin D3 analogues including 26,27-hexadeutero-25 hydroxyvitamin D3 is described.