78784-65-3

Usage

Uses

Used in Pharmaceutical Industry:
6-(3-pyridinyl)-3(2H)-pyridazinone(SALTDATA: FREE) is used as a lead compound for drug discovery and development due to its potential pharmaceutical applications. It has been studied for its anti-inflammatory and anti-cancer properties, making it a valuable asset in the creation of novel therapeutic agents.
Used as an Anti-inflammatory Agent:
In the pharmaceutical industry, 6-(3-pyridinyl)-3(2H)-pyridazinone(SALTDATA: FREE) is utilized as an anti-inflammatory agent, leveraging its biological activities to mitigate inflammation and associated conditions.
Used as an Anti-cancer Agent:
6-(3-pyridinyl)-3(2H)-pyridazinone(SALTDATA: FREE) is also used as an anti-cancer agent, where its potential to combat cancer cells is being explored for the development of new oncology treatments.
Used as an Enzyme Inhibitor:
Furthermore, 6-(3-pyridinyl)-3(2H)-pyridazinone(SALTDATA: FREE) has shown potential as an inhibitor of certain enzymes involved in disease processes. This application is crucial in the pharmaceutical industry for the development of targeted therapies that can regulate specific biochemical pathways.
Used in the Synthesis of Novel Pharmaceutical Compounds:
6-(3-pyridinyl)-3(2H)-pyridazinone has been reported in the literature as a key intermediate in the synthesis of novel pharmaceutical compounds. Its role in the creation of new drug candidates highlights its importance in the ongoing pursuit of innovative treatments.

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 298-12-4 Glyoxilic acid 
• 61192-47-0 methyl 4-oxo-4-(pyridin-3-yl)butyrate 
• 1692-25-7 3-pyridylboronic acid 
• 78784-66-4 3-chloro-6-(pyridin-3-yl)pyridazine 
• 1338225-39-0 C₉H₉NO₄ 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 80886-21-1 (Z)-4-Oxo-4-pyridin-3-yl-but-2-enoic acid 

Downstream Products

• 894002-55-2 C₁₇H₁₅N₃S 
• 923061-40-9 C₁₆H₁₂ClN₃S 
• 1621689-02-8 3-(6-oxo-3-pyridin-3-yl-6H-pyridazin-1-ylmethyl)benzoic acid methyl ester 

Relevant academic research and scientific papers

EAAT2 ACTIVATORS AND METHODS OF USING THEREOF

Disclosed are compounds that activate excitatory amino acid transporter 2 (EAAT2), as well as methods of using these compounds to treat or preventing diseases, disorders, and conditions associated with glutamate excitotoxicity.

Discovery of substituted pyrazol-4-yl pyridazinone derivatives as novel c-Met kinase inhibitors

A series of pyridazin-3-one substituted with morpholino-pyrimidine derivatives was synthesized and evaluated as tyrosine kinase inhibitors against c-Met enzyme, and anti-proliferative activities of Hs746T human gastric cancer cell line. Most of compounds exhibited good biological activity, while compound 10, 12a, 14a displayed excellent c-Met enzyme inhibitory activities and Hs746T cell-based activities.

Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses. A thiopyridazine derivative has been found to increase EAAT2 protein levels in astrocytes. A structure-activity relationship study revealed that several components of the molecule were required for activity, such as the thioether and pyridazine. Modification of the benzylthioether resulted in several derivatives (7-13, 7-15 and 7-17) that enhanced EAAT2 levels by >6-fold at concentrations 50 of 0.5 μM.

COUPLING OF ORGANOTIN REAGENTS WITH ARYL, ACYL AND HETEROARYL HALIDES: SYNTHESIS OF PYRIDAZINE AND QUINOXALONE DERIVATIVES

Couplin of organotin reagents Bu3SnAr (Ar = 2- or 3-thienyl, 2- or 3-pyridyl) with ClCOCH2CH2CO2Et in the presence of PdCl(CH2Ph)(PPh3)2 yields β-ketoesters ArCOCH2CH2CO2Et which were converted with hydrazine hydrate into 6-substituted 4,5-dihydropyridazin-3(2H)-ones, and thence to 3-halogeno-6-substituted pyridazines.The latter also couple under similar conditions with Bu3SnAr to yield 3-heteroarylpyridazines.With catalysts, coupling of ClCOCO2Et and Bu3SnAr proceeds with loss of carbon monoxide giving ArCO2Et, but without catalyst ArCOCO2Et is formed from which the3-heteroarylquinoxalin-3-one is prepared.The reactions of Bu3SnAr with 4-XC6H4Br (X = H,-OMe, -CN, -NO2) are also described.

Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. IV. 2-[2-(1-imidazolyl)ethyl]-4-(3-pyridyl)-1(2H)-phthalazinones

Synthesis and pharmacological evaluation of several compounds related to 2-[2-(1-imidazolyl)ethyl]-4-(3-pyridyl)-1(2H)-phthalazinones are described. The phenyl moiety of the phthalazinone skeleton was found to play an important role in both thromboxane A

One-pot preparation of 6-substituted 3(2H)-pyridazinones from ketones

A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2'-hydroxyacetophenone and with basic hetero-aromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.

6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines

This disclosure describes novel 6- and 8-heteroaryl and substituted 6- and 8-heteroaryl-1,2,4-triazolo[4,3-b]-pyridazines and their use as agents for treating anxiety.