78812-64-3

Usage

Uses

Used in Pharmaceutical Industry:
2-HYDROXY-1-(4-IODOPHENYL)ETHANONE is used as a synthetic intermediate for the development of new drug compounds. Its presence of the iodine atom makes it an important reagent in chemical reactions, contributing to its potential utility in the synthesis of various organic compounds with therapeutic properties.
Used in Agrochemical Industry:
2-HYDROXY-1-(4-IODOPHENYL)ETHANONE is used as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and reactivity allow for the development of novel compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Organic Synthesis:
2-HYDROXY-1-(4-IODOPHENYL)ETHANONE is used as a versatile building block in organic synthesis for the preparation of various organic compounds. Its unique structure and reactivity make it a valuable precursor for the synthesis of a wide range of chemical products, including pharmaceuticals, agrochemicals, and other industrial applications.

InChI:InChI=1/C8H7IO2/c9-7-3-1-6(2-4-7)8(11)5-10/h1-4,10H,5H2

Upstream product

• 13329-40-3 4-Iodoacetophenone 
• 2351-50-0 4-iodostyrene 

Relevant academic research and scientific papers

Dual Role of H2O2 in Palladium-Catalyzed Dioxygenation of Terminal Alkenes

A palladium-catalyzed, environmentally friendly dioxygenation reaction of simple alkenes has been developed that enabled rapid assembly of valuable α-hydroxy ketones with high atom economy. Notably, control experiments and 18O isotope-labeling experiments established that H2O2 played a dominant dual role in this transformation.

Oxidative coupling of terminal alkyne with α-hydroxy ketone: An expedient approach toward ynediones

An efficient and mild copper-catalyzed one-pot approach toward ynediones has been established. A variety of ynediones were constructed directly through oxidative coupling of alkyne with α-hydroxy ketone. Oxygen-oxidizing and neutral conditions in one-pot for a wide range of substrates including natural product derivatives make this transformation highly efficient and practical. On the basis of control experiments, in situ IR measurements, and isotopic labeling experiments, a plausible mechanism involving intermediate phenylglyoxal was drawn. Applications by synthesis of various heterocycles were also investigated.

An efficient method for the synthesis of α-hydroxyalkyl aryl ketones

Exposure of alkyl aryl ketones to Oxone/trifluoroacetic anhydride in the presence of a catalytic amount of iodobenzene affords α-hydroxyalkyl aryl ketones in good yield. This method provides an effective and economical entry for the installation of α-hydroxy moieties into ketones and should find wide application in the construction of the α-hydroxy ketone subunit in natural product synthesis.

DIRECT α-HYDROXYLATION OF KETONES USING IODOSOBENZENE

Ketones are converted smoothly into the corresponding acyloin with a high degree of selectivity upon treatment with iodosobenzene or phenyl-iodosodiacetate in methanolic sodium hydroxyde.