78816-93-0Relevant academic research and scientific papers
Chemical conversion of cyclic α-amino acids to cyclic α-aminophosphonic acids
Kaname,Mashige,Yoshifuji
, p. 531 - 536 (2007/10/03)
The oxidative decarboxylation of cyclic α-amino acids having urethane-type N-protecting groups with lead tetraacetate [Pb(OAc)4] gave 2-hydroxy derivatives, which were transformed into the corresponding α-aminophosphonic acid esters by treatment of trialkyl phosphites in the presence of Lewis acids. Deprotection and ester cleavage of the products in the usual manner afforded cyclic α-aminophosphonic acids. The convenient chemical conversion of five- and six-membered cyclic α-amino acids to the corresponding cyclic α-aminophosphonic acids has been accomplished.
