78831-84-2Relevant academic research and scientific papers
Discovery and characterization of the N-phenyl-N′-naphthylurea class of p38 kinase inhibitors
Cirillo, Pier F.,Hickey, Eugene R.,Moss, Neil,Breitfelder, Steffen,Betageri, Raj,Fadra, Tazmeen,Gaenzler, Faith,Gilmore, Thomas,Goldberg, Daniel R.,Kamhi, Victor,Kirrane, Thomas,Kroe, Rachel R.,Madwed, Jeffrey,Moriak, Monica,Netherton, Matthew,Pargellis, Christopher A.,Patel, Usha R.,Qian, Kevin C.,Sharma, Rajiv,Sun, Sanxing,Swinamer, Alan,Torcellini, Carol,Takahashi, Hidenori,Tsang, Michele,Xiong, Zhaoming
scheme or table, p. 2386 - 2391 (2009/12/07)
An effort aimed at exploring structural diversity in the N-pyrazole-N′-naphthylurea class of p38 kinase inhibitors led to the synthesis and characterization of N-phenyl-N′-naphthylureas. Examples of these compounds displayed excellent inhibition of TNF-α production in vitro, as well as efficacy in a mouse model of lipopolysaccharide induced endotoxemia. In addition, perspective is provided on the role of a sulfonamide functionality in defining inhibitor potency.
