78834-75-0Relevant articles and documents
Intermediate for preparing n-7 -2 - halogenoisoheptanoic acid ethyl ester as well as synthesis method and application thereof
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Paragraph 0056-0058, (2019/10/15)
The invention relates to an intermediate for preparing 7-halogen-2-oxo ethyl oenanthate as well as a synthetic method and an application thereof. The application is preparation of 7-halogen-2-oxo ethyl oenanthate by the intermediate. 7-halogen-2-hydroyxl heptamide is prepared by means of a novel synthetic method. The 7-halogen-2-hydroyxl heptamide has good chemical stability and heat stability, and is easily purified, so that the process flow of preparing the 7-halogen-2-oxo ethyl oenanthate is simplified, the cost is lowered, the production environment is improved, and scaled production is facilitated.
Synthesis method of ethyl 7-chloro-2-oxohepanoate
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Paragraph 0008; 0010-0018; 0029, (2018/11/22)
The invention discloses a synthesis method of ethyl 7-chloro-2-oxohepanoate. According to the synthesis method, Mg, 1-bromo-5-chloropentane, tetrahydrofuran, hydrochloric acid, NaHCO3, chlorinated polystyrene resin, imidazole, acetonitrile and diethyl oxalate are used as main raw materials. The synthesis method is characterized by carrying out addition and hydrolysis reaction of diethyl oxalate and 1-bromo-5-chloropentane in the presence of an immobilized ionic catalyst PSIM-MgBr to obtain ethyl 7-chloro-2-oxohepanoate. Compared with the conventional synthesis method, the raw materials are used for directly preparing ethyl 7-chloro-2-oxohepanoate through activation reaction of the catalyst; the yield is greatly improved; the process flows and the production cost are reduced.
Purification method of ethyl 7-chloro-2-oxoheptanoate
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Paragraph 0083; 0087, (2017/01/19)
The invention provides a purification method of ethyl 7-chloro-2-oxoheptanoate, wherein the purification method comprises the steps: firstly, carrying out a reaction of ethyl 7-chloro-2-oxoheptanoate oil crude product and a hydrosulphite solution, and separating to obtain a sulfite solid of ethyl 7-chloro-2-oxoheptanoate; then, dissolving the sulfite solid of ethyl 7-chloro-2-oxoheptanoate in water, adding an acid or alkali at a certain temperature, and decomposing the sulfite of ethyl 7-chloro-2-oxoheptanoate into ethyl 7-chloro-2-oxoheptanoate; and finally, extracting with an organic solvent immiscible with water, to obtain ethyl 7-chloro-2-oxoheptanoate having the purity improved. The method is simple in operation and suitable for industrialized production, and ensures the purity of a subsequent product and final product cilastatin sodium.