78840-52-5Relevant academic research and scientific papers
18F-Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [18F]Fluoride
Khotavivattana, Tanatorn,Verhoog, Stefan,Tredwell, Matthew,Pfeifer, Lukas,Calderwood, Samuel,Wheelhouse, Katherine,Leecollier, Thomas,Gouverneur, Vronique
supporting information, p. 9991 - 9995 (2015/08/19)
We report that halogenophilic silver(I) triflate permits halogen exchange (halex) nucleophilic 18F-fluorination of aryl-OCHFCl, -OCF2Br and -SCF2Br precursors under mild conditions. This AgI-mediated process allows for the first time access to a range of 18F-labeled aryl-OCHF2, -OCF3 and -SCF3 derivatives, inclusive of [18F]riluzole. The 18F-labeling of these medicinally important motifs expands the radiochemical space available for PET applications. A halogen exchange (halex) 18F-fluorination process offers access for the first time to 18F-labeled arylOCF3, arylOCHF2 and arylSCF3, three motifs of established medicinal importance in PET radiotracers. The use of silver(I) triflate is critical to permit 18F-labeling under mild conditions.
Electrophilic difluoro(phenylthio)methylation: Generation, stability, and reactivity of α-fluorocarbocations
Betterley, Nolan M.,Surawatanawong, Panida,Prabpai, Samran,Kongsaeree, Palangpon,Kuhakarn, Chutima,Pohmakotr, Manat,Reutrakul, Vichai
supporting information, p. 5666 - 5669 (2013/12/04)
Electrophilic difluoro(phenylthio)methylation of allylsilanes has been achieved using bromodifluoro(phenylthio)methane (PhSCF2Br) and silver hexafluoroantimonate (AgSbF6). The structural assignment and observation of α-fluorocarbocation were substantiated by NMR and theoretical calculations. Detailed mechanistic and electronic studies have provided a fundamental understanding of the reactivity and stability of the difluoro(phenylthio)methylium cation (PhSCF2+).
PREPARATION OF BROMODIFLUOROMETHYL SULFIDE AND ITS CONVERSION TO TRIFLUOROMETHYL SULFIDE
Suda, Minoru,Hino, Chiaki
, p. 1997 - 2000 (2007/10/02)
Bromodifluoromethyl sulfides are prepared by the reaction of mercaptides with CF2BrX (x=Br,Cl).And treatment of bromodifluoromethyl sulfides with various inorganic fluorides produced trifluoromethyl sulfides.
