403-66-7

Basic information

• Product Name: 4-(Trifluoromethylthio)nitrobenzene
• Synonyms: (4-Nitrophenyl)(trifluoroMethyl)sulfane;p-nitrophenyl trifluoromethyl sulfide;4-(TRIFLUOROMETHYLTHIO)NITROBENZENE;4-Nitrophenyl trifluoromethyl sulphide;1-NITRO-4-TRIFLUOROMETHYLSULFANYL-BENZENE;4-(TRIFLUOROMETHYLTHIO)NITROBENZENE,98%
• CAS NO: 403-66-7
• Molecular Formula: C₇H₄F₃NO₂S
• Molecular Weight: 223.17
• Mol File: 403-66-7.mol
• Article Data: 52

Chemical Properties

• Boiling Point: 201.4 °C at 760 mmHg
• Flash Point: 75.6 °C
• Appearance: /
• Density: 1.5 g/cm³
• CAS DataBase Reference: 4-(Trifluoromethylthio)nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Trifluoromethylthio)nitrobenzene(403-66-7)
• EPA Substance Registry System: 4-(Trifluoromethylthio)nitrobenzene(403-66-7)

Safety Data

• Hazardous Substances Data: 403-66-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 6677, 1992 DOI: 10.1016/S0040-4039(00)61016-X

Upstream product

• 713-66-6 4-nitrophenyl trichloromethylsulfide 
• 15223-20-8 1-methyl-4-{[(trifluoromethyl)sulfanyl]sulfonyl}benzene 
• 100-01-6 4-nitro-aniline 
• 3872-23-9 Copper(I) trifluoromethanethiolate 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 937-32-6 4-nitrobenzenesulfenyl chloride 
• 75-46-7 trifluoromethan 
• 2137-92-0 4-nitrophenyl thiocyanate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 75-63-8 Bromotrifluoromethane 
• 1849-36-1 para-nitrobenzenethiol 
• 78840-52-5 1-{[bromo(difluoro)methyl]sulfanyl}-4-chlorobenzenenzene 
• 13113-79-6 sodium 4-nitrobenzenethiolate 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 432-87-1 1-nitro-4-(trifluoromethylsulfonyl)benzene 
• 372-16-7 thioorthocarbonotrifluoridic acid 4-amino-phenyl ester 
• 944-30-9 p-fluorophenyl trifluoromethyl sulfone 
• 432-84-8 4-Hydroxyphenyltrifluoromethylsulphone 
• 326-45-4 SKA-19 
• 95448-39-8 imino(4-nitrophenyl)(trifluoromethyl)-λ⁶-sulfanone 
• 1948-05-6 (3-Amino-phenyl)-trifluormethyl-sulfoxid 
• 942-39-2 1-fluoro-4-((trifluoromethyl)sulfinyl)benzene 
• 1948-06-7 <3-Nitro-phenyl>-trifluormethyl-sulfoxid 
• 703-18-4 phenyl trifluoromethyl sulfoxide 
• 22351-79-7 2,4-dinitrophenyl trifluoromethyl sulfone 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 456-56-4 phenyl trifluoromethylsulfide 
• 588-81-8 thioacetic acid-(4-trifluoromethylsulfanyl-anilide) 

Relevant articles and documents

Method for synthesizing nitro (hetero) aromatic hydrocarbon

The invention discloses a method for synthesizing nitro (hetero) aromatic hydrocarbon, and belongs to the field of organic synthesis. According to the method, simple (hetero) aromatic hydrocarbon is taken as an initial raw material and is stirred and reacted in an organic solvent at 40-100 DEG C under the action of a nitration reagent, a lewis acid catalyst and protective gas, and nitro (hetero) aromatic hydrocarbon can be obtained. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good chemical selectivity, wide substrate application range, easy amplification and the like, has great application potential, and lays a good foundation for industrial production.

Transition-Metal-Free Synthesis of Aryl Trifluoromethyl Thioethers through Indirect Trifluoromethylthiolation of Sodium Arylsulfinate with TMSCF3

Herein, we report an indirect trifluoromethylthiolation of sodium arylsulfinates. This transition-metal-free reaction significantly provides an environmentally friendly and practical synthetic method for aryl trifluoromethyl thioethers using commercial Ruppert-Prakash reagent TMSCF3. This approach is also a potential alternative to the current industrial production method owing to facile substrates, excellent functional group compatibility, and operational simplicity.

Electrochemical Trifluoromethylation of Thiophenols with Sodium Trifluoromethanesulfinate

We developed an electrochemical trifluoromethylation of thiophenols without the use of metal catalysts and oxidants. This reaction features mild reaction conditions, readily available substrate, as well as moderate to good yields. In addition, this protocol can be easily scaled up with moderate efficiency.