78846-76-1Relevant academic research and scientific papers
Method for synthesizing p-nitrobenzenesulfonic
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Paragraph 0008, (2016/10/07)
The invention relates to a method for synthesizing p-nitrobenzenesulfonic and belongs to the technical field of organic chemical synthesis. The method comprises the steps of subjecting benzene serving as the raw material and sulfuric acid to sulfonation to obtain benzenesulfonic acid; pumping chlorine into benzenesulfonic acid, adding deionized water and zinc dibutyl dithiocaarbamate, and stirring the mixture; adding nitric acid and acetic anhydride into the mixture for water-bath heating, and then performing cooling through ice water; slowly adding a sodium hydroxide solution dropwise into the cooled mixture, performing heating reflux after dropping reaction, cooling the mixture to the room temperature, and obtaining p-nitrobenzenesulfonic through separation, recovery and drying. The method has the advantages that the reaction time is shortened by 30% of time needed by a 3-nitrobenzene acid synthesis method, pollution cannot be produced during reaction, and operation steps are simple.
Micro determination of furosemide pure and some of its pharmaceutical preparations with ammonium hexanitratocerate (IV) reagent
Suraiya, Afshan,Singh, Siddharth,Chauhan
experimental part, p. 1799 - 1802 (2012/06/15)
A new method has been developed for the micro determination of furosemide pure and some of its pharmaceutical preparations by using Ce(IV) reagent as oxidant. The method is simple, accurate, sensitive and gives reproducible results within ± 1% error. Effects of different variables have been studied and SD & CV calculated. Recovery experiment is carried out by standard drug addition method. A probable reaction mechanism has also been suggested. Interference of various ions has been studied.
