27886-58-4

Usage

Uses

Used in Dye and Pigment Production:
2-Chloro-benzenesulfonic acid is utilized as a key intermediate in the synthesis of various dyes and pigments, contributing to the coloration and stability of these products in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-Chloro-benzenesulfonic acid serves as a crucial building block for the development of new drugs, leveraging its chemical properties to create active pharmaceutical ingredients.
Used as a Chemical Intermediate:
2-Chloro-benzenesulfonic acid is employed as a versatile intermediate in the synthesis of a wide array of chemicals, showcasing its utility across various chemical processes and industries.

Upstream product

• 108-90-7 chlorobenzene 
• 20677-52-5 3-chlorobenzenesulphonic acid 
• 2905-23-9 2-chlorophenylsulfonyl chloride 
• 75-34-3 1,1-dichloroethane 
• 7446-11-9 sulfur trioxide 
• 7732-18-5 water 
• 7494-46-4 phenyl-methanesulfonic acid ; sodium salt 
• 7782-50-5 chlorine 
• 98-11-3 benzenesulfonic acid 
• 71-43-2 benzene 
• 38980-51-7 1-chloro-2-(4-chlorophenylsulfonyl)benzene 

Downstream Products

• 98-66-8 4-chloro-benzenesulfonic acid 
• 78846-76-1 2-chloro-4-nitrobenzene sulfonic acid 

Relevant academic research and scientific papers

Aryl sulfonic acid ammonium salt compound, preparation method and application thereof (by machine translation)

The invention discloses a aryl sulfonic acid ammonium salt compound, preparation method and application thereof, the main process expressed as follows: formula (I) indicated by the aryl sulfonic acid compound crude product as raw material, in the solvent with the structural formula (II) shown in mixed organic amine, to form the structural formula (III) as shown by a aryl sulfonic acid ammonium salt; the resulting structural formula (III) aryl sulfonic acid ammonium salt shown by the alkali soluble acid or directly to obtain the acid of formula (I) shown in the purification of compounds such as aryl sulfonic acid. The invention is primarily embodied in the [...]: through the low quality aryl sulfonic acid compound refining, effectively reduces the content of harmful impurities, improve the quality of the aryl sulfonic acid compound, reducing the pressure of the downstream use, the process is stable. (by machine translation)

Preparation method of aromatic sulfonic acid compound

The invention discloses a preparation method of an aromatic sulfonic acid compound, and aims to provide the preparation method of the aromatic sulfonic acid compound, wherein the method is simple in process, low in equipment requirements, high in capacity, wide in raw material sources and small in environmental influence. The method is characterized by comprising the steps: with a starting material aromatic amine compound, dissolving in an acid, carrying out a diazotization reaction with sodium nitrite to prepare a diazocompound; carrying out a reaction of a catalyst cuprous salt with a thionyl chloride aqueous solution, and carrying out a sulfonylation reaction with the prepared diazocompound to obtain an aromatic sulfonyl chloride compound or an aromatic sulfonyl chloride hydrochloride compound, next hydrolyzing to obtain a crude product aromatic sulfonic acid compound, finally purifying through a beating way by an acidic solvent and an alcohol solution, and thus obtaining the high-purity aromatic sulfonic acid compound. The method is friendly to environment, has certain cost advantages, avoids use of more expensive aromatic thiol compounds as starting materials, and is beneficial for industrial production.

Method for synthesizing p-nitrobenzenesulfonic

The invention relates to a method for synthesizing p-nitrobenzenesulfonic and belongs to the technical field of organic chemical synthesis. The method comprises the steps of subjecting benzene serving as the raw material and sulfuric acid to sulfonation to obtain benzenesulfonic acid; pumping chlorine into benzenesulfonic acid, adding deionized water and zinc dibutyl dithiocaarbamate, and stirring the mixture; adding nitric acid and acetic anhydride into the mixture for water-bath heating, and then performing cooling through ice water; slowly adding a sodium hydroxide solution dropwise into the cooled mixture, performing heating reflux after dropping reaction, cooling the mixture to the room temperature, and obtaining p-nitrobenzenesulfonic through separation, recovery and drying. The method has the advantages that the reaction time is shortened by 30% of time needed by a 3-nitrobenzene acid synthesis method, pollution cannot be produced during reaction, and operation steps are simple.

PROCESSES FOR PREPARING 4-CHLOROBENZENESULFONIC ACID AND 4,4'-DICHLORODIPHENYL SULFONE

The invention relates to a process for preparing 4-chlorobenzenesulfonic acid from 2-chlorobenzenesulfonic acid and/or 3-chlorobenzenesulfonic acid, comprising the conversion of 2-chlorobenzenesulfonic acid and/or 3-chlorobenzenesulfonic acid to 4-chlorobenzenesulfonic acid in the presence of sulfuric acid at a temperature of 100 to 300° C. The present invention further relates to a process for preparing 4,4′-dichlorodiphenyl sulfone, comprising said process for preparing 4-chlorobenzenesulfonic acid.

Clean-chemistry sulfonation of aromatics

A solution of TFAA/H2SO4 is an atom-efficient liquid-phase system for rapid sulfonation of aromatic structures; H2SO4 is consumed stoichiometrically and the spent trifluoroacetic anhydride (TFAA) is readily recovered as trifluoroacetic acid (TFA) which can be recycled to TFAA.

Amidino derivatives and their use as thrombin inhibitors

There is provided compounds of formula I, wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

KINETICS AND MECHANISM OF HYDROLYSIS OF AROMATIC SULFONYL CHLORIDES IN AQUEOUS SULFURIC ACID SOLUTIONS

The kinetics of the hydrolysis of 12 aromatic sulfonyl chlorides were studied by a spectrophotometric method in water and aqueous sulfuric acid solutions ( 1.0 - 60.5 wt.percent ) at 25 deg C and in 50percent sulfuric acid at several temperatures.It was shown that the reaction obeys the single-parameter equation log keff = log k0 + m'X, in which keff and k0 are the first-order rate constants in a solution with "excess acidity" X and in water respectively.The coefficient m' depends on the substituent in the ring and is equal to -0.85 to -0.38.The activity of the water does not enter into the equation for the calculation of keff.For the hydrolysis of nine substituted sulfonyl chlorides in 50percent sulfuric acid a satisfactory correlation is observed between log keff and the Σ?0.Palm induction constants ( ρ = -1.85 +/- 0.12 ).A reaction mechanism is proposed in which the rate-determining stage in the hydrolysis of the ArSO2Cl is the transformation of the complex H2O...SO2(Cl)Ar, in the form of which all the sulfonyl chloride dissolved in the water is present, into the reaction products.

HYDROLYSIS OF AROMATIC SULFONIC ACIDS UNDER THERMODYNAMIC CONTROL OF THE REACTION

Linear mathematical models which describe the hydrolysis of alkyl- and halobenzenesulfonyl acids under the conditions for their isomerization in sulfuric acid have been obtained by the method of mathematical experiment planning.The value of the effective rate constants of hydrolysis calculated according to the models for comparative conditions (150 deg C, 3 moles of 85percent sulfuric acid) were used to obtain the correlation between log kh and the ? constants of the substituents.The correlation corresponds the electrophilic nature of the hydrolysis process (ρ = -4.69).The strong influence of the electronic effects of the substituents on the rate of hydrolysis is an indication of the development of a considerable positive charge on the reaction center in the transition state.